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Addressing the dichotomy between individual and societal approaches to personalised medicine in oncology
- Source :
- European Journal of Cancer, 114, pp. 128-136, European Journal of Cancer, 114, 128-136, European Journal of Cancer, 114, 128-136. ELSEVIER SCI LTD
- Publication Year :
- 2019
-
Abstract
- Academic, industry, regulatory leaders and patient advocates in cancer clinical research met in November 2018 at the Innovation and Biomarkers in Cancer Drug Development meeting in Brussels to address the existing dichotomy between increasing calls for personalised oncology approaches based on individual molecular profiles and the need to make resource and regulatory decisions at the societal level in differing health-care delivery systems around the globe. Novel clinical trial designs, the utility and limitations of real-world evidence (RWE) and emerging technologies for profiling patient tumours and tumour-derived DNA in plasma were discussed. While randomised clinical trials remain the gold standard approach to defining clinical utility of local and systemic therapeutic interventions, the broader adoption of comprehensive tumour profiling and novel trial designs coupled with RWE may allow patient and physician autonomy to be appropriately balanced with broader assessments of safety and overall societal benefit. (C) 2019 Published by Elsevier Ltd.
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Emerging technologies
media_common.quotation_subject
Cancer drugs
Psychological intervention
Medical Oncology
Societal level
GUIDELINES
03 medical and health sciences
0302 clinical medicine
Clinical trials
Internal medicine
medicine
Humans
Profiling (information science)
Precision Medicine
Health technology assessment
Evidence-driven optimal health-care delivery
media_common
Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17]
Clinical trial
030104 developmental biology
Clinical research
030220 oncology & carcinogenesis
Molecular and immunologic profiling
Psychology
ACCESS
Autonomy
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 09598049
- Volume :
- 114
- Database :
- OpenAIRE
- Journal :
- European Journal of Cancer
- Accession number :
- edsair.doi.dedup.....065a865995916dc6e9a0afd348575ec7