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Enhanced tissue adhesiveness of injectable gelatin hydrogels through dual catalytic activity of horseradish peroxidase
Enhanced tissue adhesiveness of injectable gelatin hydrogels through dual catalytic activity of horseradish peroxidase
- Source :
- Biopolymers. 109(1)
- Publication Year :
- 2017
-
Abstract
- Development of bioadhesives with tunable mechanical strength, high adhesiveness, biocompatibility, and injectability is greatly desirable in all surgeries to replace or complement the sutures and staples. Herein, the dual catalytic activity of horseradish peroxidase is exploited to in situ form the hydroxyphenyl propionic acid-gelatin/thiolated gelatin (GH/GS) adhesive hydrogels including two alternative crosslinks (phenol-phenol and disulfide bonds) with fast gelation (few seconds - several minutes) and improved physicochemical properties. Their elastic moduli increase from 6.7 to 10.3 kPa by adding GS polymer that leads to the better stability of GH/GS hydrogels than GH ones. GH/GS adhesive strength is respectively 6.5-fold and 15.8-fold higher than GH-only and fibrin glue that is due to additional disulfide linkages between hydrogels and tissues. Moreover, in vitro cell study with human dermal fibroblast showed the cell-compatibility of GH/GS hydrogels. Taken together, GH/GS hydrogels can be considered as promising potential adhesive materials for various biomedical applications.
- Subjects :
- food.ingredient
Biocompatibility
Swine
Biophysics
macromolecular substances
02 engineering and technology
010402 general chemistry
01 natural sciences
Biochemistry
Horseradish peroxidase
Gelatin
Biomaterials
Dermal fibroblast
food
Polymer chemistry
Animals
Fibrin glue
Horseradish Peroxidase
chemistry.chemical_classification
biology
Chemistry
Organic Chemistry
technology, industry, and agriculture
Hydrogels
General Medicine
Polymer
021001 nanoscience & nanotechnology
0104 chemical sciences
Self-healing hydrogels
biology.protein
Tissue Adhesives
Adhesive
0210 nano-technology
Subjects
Details
- ISSN :
- 10970282
- Volume :
- 109
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Biopolymers
- Accession number :
- edsair.doi.dedup.....066460e60acba1175e0110c3ed20373a