Oxygen therapy in preterm infants with pulmonary hypertension

Premature neonates 30-55mm Hg promotes pulmonary vasodilation. Targeting saturations of 80-85% by 5min, 85-95% by 10min during resuscitation and 90-95% during the postnatal course are appropriate targets for routine management of preterm infants. Among preterm infants with PHT, avoiding hypoxia/hyperoxia by titrating supplemental oxygen to maintain saturations in low to mid 90s with alarm limits at 90 and 97% seems to be a reasonable approach pending further studies. Further high-quality evidence generated from randomized trials is required to guide oxygen therapy in preterm PHT.