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Interferon-alpha-induced thyroid dysfunction in patients with chronic active hepatitis C: a transient, reversible and self-limited dysfunction
- Source :
- Internal medicine (Tokyo, Japan). 37(1)
- Publication Year :
- 1998
-
Abstract
- To survey the prognoses of interferon-alpha (IFNα)-induced thyroid dysfunction, a total of 100 patients (49 males and 51 females) with biopsy-proven chronic active hepatitis C were studied. Either during or after IFNα therapy, 29 patients (33.7 %) revealed suppression/elevation of thyroid stimulating hormone (TSH) or both, transient thyrotoxicosis (TSH less than 0.1 μU/ml) or transient hypothyroidism (TSH 5.0-190.95 μU/ml). However, the thyroid function normalized without supplementation of the thyroid hormone in the follow-up period. In the same period, one of the 14 control patients (7.1 %) developed thyroid dysfunction. Thyroid abnormalities developed significantly more in patients with IFNα therapy than in those without IFNα therapy. The findings suggest that the occult autoimmune disorder becomes overt with IFNαtreatment in patients with pre-existent autoimmune thyroid disease. IFNα-induced thyroid dysfunction is transient, reversible and self-limited. It is not necessary to discontinue IFNα therapy when thyroid dysfunction develops.(Internal Medicine 37: 27-31, 1998)
- Subjects :
- Adult
Male
endocrine system
medicine.medical_specialty
Thyroiditis
endocrine system diseases
medicine.medical_treatment
Alpha interferon
Thyrotropin
Interferon alpha-2
Autoimmune Diseases
Thyroid-stimulating hormone
Hypothyroidism
Internal medicine
Internal Medicine
medicine
Humans
Prospective Studies
Chronic thyroiditis
Interferon alfa
Aged
Chemotherapy
business.industry
Goiter
Thyroid
Interferon-alpha
General Medicine
Hepatitis C, Chronic
Middle Aged
Prognosis
Thyroid Diseases
Recombinant Proteins
Thyroxine
Endocrinology
medicine.anatomical_structure
Female
Thyroid function
business
medicine.drug
Hormone
Subjects
Details
- ISSN :
- 09182918
- Volume :
- 37
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Internal medicine (Tokyo, Japan)
- Accession number :
- edsair.doi.dedup.....066d63f54deaf4892e4520c53b06ea35