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Interferon-alpha-induced thyroid dysfunction in patients with chronic active hepatitis C: a transient, reversible and self-limited dysfunction

Authors :
Kumiko Tsuboi
Toru Nagayama
Yukitaka Miyachi
Masahiko Katayama
Hana Matoba
Taeko Ooya
Fumie Ihara
Rena Yuasa
Sachio Otsuka
Kenji Matsuo
Source :
Internal medicine (Tokyo, Japan). 37(1)
Publication Year :
1998

Abstract

To survey the prognoses of interferon-alpha (IFNα)-induced thyroid dysfunction, a total of 100 patients (49 males and 51 females) with biopsy-proven chronic active hepatitis C were studied. Either during or after IFNα therapy, 29 patients (33.7 %) revealed suppression/elevation of thyroid stimulating hormone (TSH) or both, transient thyrotoxicosis (TSH less than 0.1 μU/ml) or transient hypothyroidism (TSH 5.0-190.95 μU/ml). However, the thyroid function normalized without supplementation of the thyroid hormone in the follow-up period. In the same period, one of the 14 control patients (7.1 %) developed thyroid dysfunction. Thyroid abnormalities developed significantly more in patients with IFNα therapy than in those without IFNα therapy. The findings suggest that the occult autoimmune disorder becomes overt with IFNαtreatment in patients with pre-existent autoimmune thyroid disease. IFNα-induced thyroid dysfunction is transient, reversible and self-limited. It is not necessary to discontinue IFNα therapy when thyroid dysfunction develops.(Internal Medicine 37: 27-31, 1998)

Details

ISSN :
09182918
Volume :
37
Issue :
1
Database :
OpenAIRE
Journal :
Internal medicine (Tokyo, Japan)
Accession number :
edsair.doi.dedup.....066d63f54deaf4892e4520c53b06ea35