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Effective deep brain stimulation suppresses low frequency network oscillations in the basal ganglia by regularizing neural firing patterns
- Publication Year :
- 2012
-
Abstract
- Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for the motor symptoms of Parkinson's disease (PD). The effects of DBS depend strongly on stimulation frequency: high frequencies (>90 Hz) improve motor symptoms, while low frequencies (
- Subjects :
- Deep brain stimulation
Nerve net
medicine.medical_treatment
Deep Brain Stimulation
Action Potentials
Stimulation
Motor Activity
Article
Basal Ganglia
chemistry.chemical_compound
Basal ganglia
medicine
Premovement neuronal activity
Animals
Rats, Long-Evans
Parkinson Disease, Secondary
Oxidopamine
Neurons
Behavior, Animal
Chemistry
General Neuroscience
nervous system diseases
Rats
Subthalamic nucleus
Globus pallidus
medicine.anatomical_structure
surgical procedures, operative
nervous system
Female
Nerve Net
Neuroscience
therapeutics
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....0673d9704abbc467e206e3122fa16b7b