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Interactions among IGF-1, AKT2, FOXO1, and FOXO3 variations and between genes and physical activities on physical performance in community-dwelling elders
- Source :
- PLoS ONE, PLoS ONE, Vol 15, Iss 9, p e0239530 (2020)
- Publication Year :
- 2020
- Publisher :
- Public Library of Science, 2020.
-
Abstract
- This study assessed the interactions among IGF-1, AKT2, FOXO1, and FOXO3 variations and the interactions of gene and physical activity on handgrip strength, arm muscle mass-adjusted handgrip (armGrip), gait speed (GS), timed up and go (TUG), and leg press strength (LPS). Nine single nucleotide polymorphisms (SNPs) containing three IGF-1 SNPs (rs6214, rs5742692, and rs35767), two AKT2 SNPs (rs892119 and rs35817154), two FOXO1 SNPs (rs17446593 and rs10507486), and two FOXO3 SNPs (rs9480865 and rs2153960) were genotyped in 472 unrelated elders with a mean age of 73.8 years. We observed significant interactions of IGF-1 SNP rs6214 and rs35767 with regular physical activity on TUG and GS; and AKT2 SNP rs892119 and FOXO3 SNP rs9480865 with regular physical activity on armGrip. Genotype GG of IGF-1 rs6214 and rs35767 in individuals without regular physical activity had poor performance in TUG and GS, as well as GG of AKT2 rs892119 decreased armGrip in individuals without regular physical activity. After FDR adjustment, no significant gene-gene interactions were found. A sedentary lifestyle may increase the risk of impairing physical performance and regular physical activity is a remedy for sarcopenia, even a little regular physical activity can overcome carrying some risk alleles in this pathway.
- Subjects :
- Male
Sarcopenia
Heredity
Single Nucleotide Polymorphisms
0302 clinical medicine
Elderly
Gene Frequency
Polymorphism (computer science)
Medicine and Health Sciences
Public and Occupational Health
Biomechanics
030212 general & internal medicine
Insulin-Like Growth Factor I
Leg press
Musculoskeletal System
Multidisciplinary
Hand Strength
Forkhead Box Protein O1
Muscles
Forkhead Box Protein O3
Physical Functional Performance
Genetic Mapping
Medicine
Legs
Female
Anatomy
Research Article
medicine.medical_specialty
Genotype
Science
030209 endocrinology & metabolism
Single-nucleotide polymorphism
Variant Genotypes
Biology
Polymorphism, Single Nucleotide
03 medical and health sciences
Signs and Symptoms
Hand strength
Internal medicine
medicine
Genetics
SNP
Adults
Humans
Exercise physiology
Exercise
Alleles
Sedentary lifestyle
Aged
Biology and Life Sciences
Physical Activity
medicine.disease
Endocrinology
Skeletal Muscles
Age Groups
Body Limbs
People and Places
Population Groupings
Clinical Medicine
Sedentary Behavior
human activities
Proto-Oncogene Proteins c-akt
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 15
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....0678f451549da12e2a5560c1dfd5f627