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3,5-Diiodo-L-thyronine prevents high-fat-diet-induced insulin resistance in rat skeletal muscle through metabolic and structural adaptations
- Source :
- The FASEB journal 25 (2011): 3312–3324. doi:10.1096/fj.11-181982., info:cnr-pdr/source/autori:Moreno M, Silvestri E, De Matteis R, de Lange P, Lombardi A, Glinni D, Senese R, Cioffi F, Salzano AM, Scaloni A, Lanni A, Goglia F./titolo:3,5-Diiodo-L-thyronine prevents high-fat-diet-induced insulin resistance in rat skeletal muscle through metabolic and structural adaptations./doi:10.1096%2Ffj.11-181982./rivista:The FASEB journal/anno:2011/pagina_da:3312/pagina_a:3324/intervallo_pagine:3312–3324/volume:25
- Publication Year :
- 2011
-
Abstract
- The worldwide prevalence of obesity-associated pathologies, including type 2 diabetes, requires thorough investigation of mechanisms and interventions. Recent studies have highlighted thyroid hormone analogs and derivatives as potential agents able to counteract such pathologies. In this study, in rats receiving a high-fat diet (HFD), we analyzed the effects of a 4-wk daily administration of a naturally occurring iodothyronine, 3,5-diiodo-L-thyronine (T2), on the gastrocnemius muscle metabolic/structural phenotype and insulin signaling. The HFD-induced increases in muscle levels of fatty acid translocase (3-fold; P
- Subjects :
- CD36 Antigens
Male
Diiodothyronines
Muscle Fibers, Skeletal
Type 2 diabetes
Biochemistry
chemistry.chemical_compound
Sarcolemma
Insulin
Glucose Transporter Type 4
biology
Lipids
AMINO-ACID
medicine.anatomical_structure
OBESITY
Thyronine
Signal Transduction
Biotechnology
medicine.medical_specialty
WEIGHT-LOSS
Perilipin-2
GLUCOSE-TRANSPORT
Gastrocnemius muscle
Insulin resistance
Internal medicine
Genetics
medicine
Animals
Rats, Wistar
Muscle, Skeletal
Molecular Biology
Triglycerides
proteomics AKT/PROTEIN KINASE-B
Glucose transporter
Proteomic
Membrane Proteins
nutritional and metabolic diseases
Skeletal muscle
thyroid hormone
metabolism
PROTEIN-KINASE
ACID-METABOLISM
GLYCOGEN-SYNTHESIS
medicine.disease
Dietary Fats
Rats
Thyroid hormone
Insulin receptor
Metabolism
Endocrinology
Gene Expression Regulation
chemistry
biology.protein
Insulin Resistance
Proto-Oncogene Proteins c-akt
Hormone
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- The FASEB journal 25 (2011): 3312–3324. doi:10.1096/fj.11-181982., info:cnr-pdr/source/autori:Moreno M, Silvestri E, De Matteis R, de Lange P, Lombardi A, Glinni D, Senese R, Cioffi F, Salzano AM, Scaloni A, Lanni A, Goglia F./titolo:3,5-Diiodo-L-thyronine prevents high-fat-diet-induced insulin resistance in rat skeletal muscle through metabolic and structural adaptations./doi:10.1096%2Ffj.11-181982./rivista:The FASEB journal/anno:2011/pagina_da:3312/pagina_a:3324/intervallo_pagine:3312–3324/volume:25
- Accession number :
- edsair.doi.dedup.....0692d06d53d253970e902446684d8d13