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A novel electrospun membrane based on moxifloxacin hydrochloride/poly(vinyl alcohol)/sodium alginate for antibacterial wound dressings in practical application
- Source :
- Drug Delivery. 23:818-829
- Publication Year :
- 2014
- Publisher :
- Informa UK Limited, 2014.
-
Abstract
- This study reports on the performance of sodium alginate (SA)/poly(vinyl alcohol) (PVA)/moxifloxacin hydrochloride (MH) nanofibrous membranes (NFM) capable of providing antibacterial agent delivery for wound-dressing applications. The aim of this work was to prepare antibacterial NFM with good permeability properties by employing PVA and SA as carriers. A group of 12% PVA/2% SA solutions blended in various ratios (8:2, 7:3, 6:4, 5:5 and 4:6, v/v) and containing 0.5, 1, 2 or 4 wt% MH were studied for electrospinning into nanoscale fibermats. The optimum ratio found to form smooth fibers with uniform fibrous features was 6:4. The drug release behavior of the electrospun, the antibacterial effects on Pseudomonas aeruginosa and Staphylococcus aureus and the animal wound dressing capabilities were also investigated. As much as 80% of the MH was released from the electrospun after 10 h of incubation at 37 °C. In addition, the NFM with 0.5 MH exhibited less activity, whereas those with higher concentrations of MH exhibited greater antibacterial effect. Furthermore, the MH-loaded electrospun accelerated the rate of wound dressing compared to other groups. The results of the in vitro and in vivo experiments suggest that MH/PVA/SA nanofibers might be an interesting bioactive wound dressing for clinical applications.
- Subjects :
- Male
Staphylococcus aureus
Vinyl alcohol
Materials science
Alginates
Moxifloxacin
Nanofibers
Pharmaceutical Science
02 engineering and technology
010402 general chemistry
Moxifloxacin hydrochloride
01 natural sciences
Rats, Sprague-Dawley
chemistry.chemical_compound
Glucuronic Acid
Polymer chemistry
Animals
Sodium alginate
Antibacterial agent
Wound Healing
integumentary system
Hexuronic Acids
General Medicine
021001 nanoscience & nanotechnology
Bandages
Biodegradable polymer
Electrospinning
Anti-Bacterial Agents
Rats
0104 chemical sciences
Membrane
chemistry
Polyvinyl Alcohol
Pseudomonas aeruginosa
Drug release
Female
Rabbits
0210 nano-technology
Fluoroquinolones
Nuclear chemistry
Subjects
Details
- ISSN :
- 15210464 and 10717544
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Drug Delivery
- Accession number :
- edsair.doi.dedup.....06bbb8acfc8673ec322957cec335383b