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Severity of dysfluency correlates with basal ganglia activity in persistent developmental stuttering
- Source :
- Brain and Language. 104:190-199
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Previous studies suggest that anatomical anomalies [Foundas, A. L., Bollich, A. M., Corey, D. M., Hurley, M., & Heilman, K. M. (2001). Anomalous anatomy of speech-language areas in adults with persistent developmental stuttering. Neurology, 57, 207-215; Foundas, A. L., Corey, D. M., Angeles, V., Bollich, A. M., Crabtree-Hartman, E., & Heilman, K. M. (2003). Atypical cerebral laterality in adults with persistent developmental stuttering. Neurology, 61, 1378-1385; Foundas, A. L., Bollich, A. M., Feldman, J., Corey, D. M., Hurley, M., & Lemen, L. C. et al., (2004). Aberrant auditory processing and atypical planum temporale in developmental stuttering. Neurology, 63, 1640-1646; Jancke, L., Hanggi, J., & Steinmetz, H. (2004). Morphological brain differences between adult stutterers and non-stutterers. BMC Neurology, 4, 23], in particular a reduction of the white matter anisotropy underlying the left sensorimotor cortex [Sommer, M., Koch, M. A., Paulus, W., Weiller, C., & Buchel, C. (2002). Disconnection of speech-relevant brain areas in persistent developmental stuttering. Lancet, 360, 380-383] could be at the origin of persistent developmental stuttering (PDS). Because neural connections between the motor cortex and basal ganglia are implicated in speech motor functions, PDS could also be associated with a dysfunction in basal ganglia activity [Alm, P. (2004). Stuttering and the basal ganglia circuits: a critical review of possible relations. Journal of Communication Disorders, 37, 325-369]. This fMRI study reports a correlation between severity of stuttering and activity in the basal ganglia and shows that this activity is modified by fluency shaping therapy through long-term therapy effects that reflect speech production improvement. A model of dysfunction in stuttering and possible repair modes is proposed that accommodates the data presented here and observations previously made by us and by others.
- Subjects :
- Adult
Male
Linguistics and Language
medicine.medical_specialty
Neurology
Stuttering
Adolescent
Cognitive Neuroscience
Planum temporale
Models, Neurological
Experimental and Cognitive Psychology
Basal Ganglia
Language and Linguistics
White matter
Speech and Hearing
Speech Production Measurement
Communication disorder
Basal ganglia
medicine
Humans
Language disorder
Brain Mapping
Neuronal Plasticity
Motor Cortex
Middle Aged
medicine.disease
Magnetic Resonance Imaging
nervous system diseases
medicine.anatomical_structure
medicine.symptom
Psychology
Neuroscience
Psychomotor Performance
Motor cortex
Subjects
Details
- ISSN :
- 0093934X
- Volume :
- 104
- Database :
- OpenAIRE
- Journal :
- Brain and Language
- Accession number :
- edsair.doi.dedup.....06bcb3d2eac2e5b7784f660922cd9cac