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Hypothalamo-pituitary-adrenal axis response to coronary artery embolization: an ovine model of acute myocardial infarction
- Source :
- The Journal of endocrinology. 152(3)
- Publication Year :
- 1997
-
Abstract
- Although previous studies have described the hypothalamo–pituitary–adrenal (HPA) response to the stress of acute myocardial infarction, it is not possible to study the hormone changes immediately after infarction in humans. Accordingly, we have examined the HPA response to microembolization of coronary arteries in 13 sheep compared with 5 sham control sheep. Plasma vasopressin (AVP; PP=0·005) and cortisol (P=0·005) were all increased 2 h (first sample time) after embolization. Plasma ACTH and cortisol levels returned to baseline levels by 6 h but plasma AVP levels did not return to baseline levels until more than 12 h after embolization. Plasma corticotrophin-releasing hormone (CRH) showed no significant change in response to embolization. In a subset of six animals which were sampled more frequently, the peak responses for plasma AVP, ACTH and cortisol occurred at 40 min after embolization. The maximum responses in any individual sheep observed at this time point were 744 pmol/l for AVP, 144 pmol/l for ACTH and 492 nmol/l for cortisol. CRH levels tended to increase across the first hour but these changes were not statistically significant. In conclusion, the stress hormone responses to microembolization of the coronary arteries have been defined in an ovine model of myocardial infarction. This model is suitable for studying the effects of novel treatments to reduce the stress of myocardial infarction. Journal of Endocrinology (1997) 152, 489–493
- Subjects :
- endocrine system
medicine.medical_specialty
Vasopressin
Hypothalamo-Hypophyseal System
Hydrocortisone
Corticotropin-Releasing Hormone
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Embolism
Myocardial Infarction
Infarction
Pituitary-Adrenal System
Endocrinology
Adrenocorticotropic Hormone
Internal medicine
Medicine
Animals
Embolization
Myocardial infarction
Sheep
business.industry
medicine.disease
Coronary Vessels
Coronary arteries
Arginine Vasopressin
Disease Models, Animal
medicine.anatomical_structure
Female
business
hormones, hormone substitutes, and hormone antagonists
Glucocorticoid
medicine.drug
Hormone
Subjects
Details
- ISSN :
- 00220795
- Volume :
- 152
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The Journal of endocrinology
- Accession number :
- edsair.doi.dedup.....06c461f8666c3a353e7f24efda0cb3a9