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Acylsilane Directed Rh-Catalyzed Arene C–H Alkylation with Maleimides and Visible-Light-Induced Siloxycarbene-Amide Cyclization: [3 + 2] Carbo-Annulation in Ru Catalysis
- Source :
- Organic Letters, Organic Letters, 2023, 25 (15), pp.2594-2599. ⟨10.1021/acs.orglett.3c00487⟩
- Publication Year :
- 2023
- Publisher :
- American Chemical Society (ACS), 2023.
-
Abstract
- International audience; We herein demonstrate the acylsilane-directed Rh-catalyzed arene C-H bond alkylation with maleimides. The resulting derivatives were utilized in visible-light-induced intramolecular siloxycarbene-amide cyclization for the synthesis of new tricyclic γ-lactams. In parallel, we also harnessed the same acylsilane and maleimide units through [3 + 2] carbo-annulation by using Ru-catalysis. A wide range of maleimides and aroylsilanes were used to establish the broadness of these transformations.
Details
- ISSN :
- 15237052 and 15237060
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Organic Letters
- Accession number :
- edsair.doi.dedup.....06ed83196d720b71f51cfb12963b0a7d