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Involvement of noncoding RNAs in epigenetic modifications of esophageal cancer
- Source :
- Biomedicine & Pharmacotherapy, Vol 117, Iss, Pp-(2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Esophageal cancer (EC) is a serious digestive malignancy and is a leading cause of cancer-related mortality. Apart from genetic mutations, many epigenetic alterations including DNA methylation and histone modifications associated with chromatin remodeling have been identified in the regulation of gene expression in EC. Recently, noncoding RNAs, and mainly lncRNAs and miRNAs, have been revealed to be involved in the epigenetic regulation of EC. In this review, we focus on describing new insights on epigenetic processes associated with noncoding RNAs, which have been characterized to be responsible for the development and progression of EC.
- Subjects :
- 0301 basic medicine
RNA, Untranslated
Esophageal Neoplasms
Esophageal cancer
RM1-950
Malignancy
Chromatin remodeling
Noncoding RNA
Epigenesis, Genetic
Histones
03 medical and health sciences
0302 clinical medicine
lncRNA
microRNA
medicine
Humans
Epigenetics
Pharmacology
Genetics
Regulation of gene expression
DNA methylation
biology
General Medicine
Epigenetic alteration
Chromatin Assembly and Disassembly
medicine.disease
Non-coding RNA
Gene Expression Regulation, Neoplastic
Histone Code
MicroRNAs
030104 developmental biology
Histone
030220 oncology & carcinogenesis
biology.protein
Therapeutics. Pharmacology
Histone modification
Subjects
Details
- Language :
- English
- ISSN :
- 07533322
- Volume :
- 117
- Database :
- OpenAIRE
- Journal :
- Biomedicine & Pharmacotherapy
- Accession number :
- edsair.doi.dedup.....06f87e48a271358c0716d82e675cb6d4