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Postoperative delirium in children in undergoing treatment of congenital septal heart defects
- Source :
- Вестник анестезиологии и реаниматологии, Vol 18, Iss 2, Pp 62-68 (2021)
- Publication Year :
- 2021
- Publisher :
- NEW TERRA Publishing House, 2021.
-
Abstract
- The objective: to establish the prevalence of postoperative delirium (POD) and the influence of various factors in intra- and postoperative periods on its occurrence in children with septal congenital defects requiring surgical interventions with cardiopulmonary bypass (CPB).Subjects and methods: 40 children from 6 to 36 months and weighing from 7.5 to 15 kg were enrolled in the study; they underwent planned radical surgery of septal CHD with cardiopulmonary bypass. In the postoperative period, all patients were tested using the Cornell Assessment for Pediatric Delirium validated for children of this age. Cerebral damage was also assessed using three specific serum markers: protein S-100-ß, neuron-specific enolase (NSE) and glial fibrillar acidic protein (GFAP) before the surgery, upon bypass completion, and in 16 hours after the operation.Results. The study revealed the incidence of delirium in 22.5%. When analyzing many factors of the intra- and postoperative period, it was found that the use of donor blood components in the primary volume of CPB filling was statistically significantly more often observed in patients with established delirium: 7 (78%) and 13 (42%) (p = 0.049). Also, it was found that levels of S-100-ß, NSE, and GFAP were significantly higher in patients with confirmed POD.The study described the incidence of POD in children after surgical treatment of congenital heart disease under cardiopulmonary bypass and showed that intraoperative transfusion was a risk factor for the development of delirium. The role of markers of cerebral damage in the diagnosis of POD was also proven.
- Subjects :
- Heart disease
Enolase
030204 cardiovascular system & hematology
Critical Care and Intensive Care Medicine
behavioral disciplines and activities
law.invention
03 medical and health sciences
0302 clinical medicine
delirium
children
030202 anesthesiology
law
medicine
Cardiopulmonary bypass
Risk factor
Radical surgery
congenital septal defects
business.industry
RC86-88.9
Incidence (epidemiology)
Medical emergencies. Critical care. Intensive care. First aid
medicine.disease
Anesthesiology and Pain Medicine
nervous system
Anesthesia
Congenital Septal Defect
Emergency Medicine
Delirium
medicine.symptom
business
Subjects
Details
- Language :
- Russian
- ISSN :
- 25418653 and 20785658
- Volume :
- 18
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Вестник анестезиологии и реаниматологии
- Accession number :
- edsair.doi.dedup.....070199924db27d46d4497f00f76edba7