Back to Search
Start Over
Clinical utility of contrast‐enhanced ultrasonography in the diagnosis of benign and malignant small renal masses among Asian population
- Source :
- Cancer Medicine, Cancer Medicine, Vol 8, Iss 18, Pp 7532-7541 (2019)
- Publication Year :
- 2019
- Publisher :
- John Wiley and Sons Inc., 2019.
-
Abstract
- We assessed the clinical utility of contrast‐enhanced ultrasonography (CEUS) in the diagnosis of benign and malignant small renal masses using a meta‐analysis of diagnostic test. We performed a comprehensive online search in the following database including PubMed, Embase, Web of Science, Wanfang, and Chinese National Knowledge Infrastructure from the inception to August 25, 2019. the following index were calculated for assessing the diagnostic ability, including sensitivity, specificity, diagnostic odds ratio (DOR), negative likelihood ratio (NLR), positive likelihood ratio (PLR), area under the curve (AUC) with 95% confidence intervals (CIs). Seventeen studies were included in the qualitative and quantitative analyses. The overall sensitivity was 0.93 with 95% CI of 0.88‐0.95. The specificity was 0.71 and the 95% CI was 0.60‐0.80. The pooled AUC was 0.91 (95% CI: 0.88‐0.93). The diagnostic odds ratio was 31 (95% CI: 21‐45). The NLR and PLR were 0.10 (95% CI: 0.07‐0.15) and 3.2(95% CI: 2.3‐4.4), respectively. There is a slight heterogeneity within studies. The subgroup analysis was also performed. For retrospective and perspective, the sensitivity and specificity were 0.93, 0.92 and 0.71, 0.73; For different diameter lesions, the sensitivity and specificity were 0.93, 0.94 and 0.64, 0.74; For sample size (≤median vs. >median), the sensitivity and specificity were 0.94, 0.93 and 0.67, 0.77. The Deek's funnel plot asymmetry test in indicated no publication bias. The CEUS have a high diagnostic ability in differentiating benign and malignant small renal masses among Asian population.<br />The early detection and timely treatment for small renal carcinoma become one of the most factors in improving curative effect and survival status. The CEUS have a high diagnostic ability in differentiating benign and malignant small renal masses. The CEUS has some characteristics such as non‐invasive operation, relative low cost and no radiation and can be a alternative method for those who cannot take MRI or CT
- Subjects :
- 0301 basic medicine
Male
Cancer Research
medicine.medical_specialty
Funnel plot
Asia
specificity
Subgroup analysis
small renal carcinoma
lcsh:RC254-282
Gastroenterology
Likelihood ratios in diagnostic testing
Diagnosis, Differential
03 medical and health sciences
0302 clinical medicine
Asian People
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Original Research
Aged
Ultrasonography
business.industry
Area under the curve
Clinical Cancer Research
Publication bias
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
sensitivity
Image Enhancement
Confidence interval
Kidney Neoplasms
030104 developmental biology
Oncology
ROC Curve
Sample size determination
030220 oncology & carcinogenesis
Diagnostic odds ratio
Female
Kidney Diseases
business
contrast‐enhanced ultrasonography
Publication Bias
Subjects
Details
- Language :
- English
- ISSN :
- 20457634
- Volume :
- 8
- Issue :
- 18
- Database :
- OpenAIRE
- Journal :
- Cancer Medicine
- Accession number :
- edsair.doi.dedup.....071add631924a724ab344d3a15a0f4d9