Back to Search
Start Over
Associations of Lower Caffeine Intake and Plasma Urate Levels with Idiopathic Parkinson’s Disease in the Harvard Biomarkers Study
- Source :
- J Parkinsons Dis
- Publication Year :
- 2020
- Publisher :
- IOS Press, 2020.
-
Abstract
- Two purines, caffeine and urate, have been associated with a reduced risk of idiopathic Parkinson's disease (PD) in multiple cohorts and populations. The Harvard Biomarkers Study (HBS) is a longitudinal study designed to accelerate the discovery and validation of molecular diagnostic and progression markers of early-stage PD. To investigate whether these 'reduced risk' factors are associated with PD within this cohort, we conducted a cross-sectional, case-control study in 566 subjects consisting of idiopathic PD patients and healthy controls. Caffeine intake as assessed by a validated questionnaire was significantly lower in idiopathic PD patients compared to healthy controls in males (mean difference -125 mg/day, p < 0.001) but not in females (mean difference -30 mg/day, p = 0.29). A strong inverse association was also observed with plasma urate levels both in males (mean difference -0.46 mg/dL, p = 0.017) and females (mean difference -0.45 mg/dL, p = 0.001). Both analyses stratified for sex and adjusted for age, body mass index, and either urate level or caffeine consumption, respectively. These results highlight the robustness of caffeine intake and urate as factors inversely associated with idiopathic PD.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Longitudinal study
Parkinson's disease
Gastroenterology
Article
Eating
03 medical and health sciences
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Sex Factors
0302 clinical medicine
Caffeine
Internal medicine
Humans
Medicine
Aged
business.industry
Parkinson Disease
Middle Aged
medicine.disease
Uric Acid
Cross-Sectional Studies
030104 developmental biology
chemistry
Case-Control Studies
Cohort
Uric acid
Biomarker (medicine)
Female
Neurology (clinical)
Caffeine intake
business
Body mass index
Biomarkers
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 1877718X and 18777171
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of Parkinson's Disease
- Accession number :
- edsair.doi.dedup.....07248bdfb201a6c59c7a45e713faca21