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Respiratory syncytial virus evaluation among asymptomatic and symptomatic subjects in a university hospital in Sao Paulo, Brazil, in the period of 2009-2013
- Source :
- Influenza and Other Respiratory Viruses
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Background The respiratory syncytial virus (RSV) is recognized as an important cause of respiratory tract infections. Immunocompromised patients, healthcare workers (HCWs) and children contacts are at increased risk of acquiring the infection. However, the impact of asymptomatic infection in transmission has not been well studied. Objectives: this study evaluated the frequency and viral load (VL) of RSV in nasal swab samples of individuals with different risk factors for acquiring infection in a university hospital in Sao Paulo, Brazil. Methods We included 196 symptomatic children and their 192 asymptomatic caregivers, 70 symptomatic and 95 asymptomatic HCWs, 43 samples from symptomatic HIV‐positive outpatients, and 100 samples of asymptomatic HIV patients in the period of 2009‐2013. Results RSV infection was detected in 10.1% (70/696) of samples, 4.4% (17/387) of asymptomatic patients, and 17.1% (53/309) from symptomatic patients. (P < .0001). The VL of symptomatic patients (4.7 log copies/mL) was significantly higher compared to asymptomatic patients (2.3 log copies/mL). RSV detection among asymptomatic caregivers (6.8%; 13/192) was significantly higher compared to other asymptomatic adults, HIV and HCWs (2.0%; 4/195; P = .0252). A close contact with an infected child at home was an important risk to RSV acquisition [OR 22.6 (95% CI 4.8‐106.7)]. Children who possibly transmitted the virus to their asymptomatic contacts had significantly higher viral load than children who probably did not transmit (P < .0001). Conclusions According to our results, it is important to know if people circulating inside the hospital have close contact with acute respiratory infected children.
- Subjects :
- Adult
Male
0301 basic medicine
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Epidemiology
Health Personnel
respiratory syncytial virus
030106 microbiology
Respiratory Syncytial Virus Infections
Nose
Real-Time Polymerase Chain Reaction
Asymptomatic
Virus
Hospitals, University
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
asymptomatic
030212 general & internal medicine
Respiratory system
Child
Asymptomatic Infections
Close contact
Respiratory tract infections
business.industry
Transmission (medicine)
Public Health, Environmental and Occupational Health
Infant
Original Articles
Middle Aged
Viral Load
University hospital
Respiratory Syncytial Viruses
Surgery
Infectious Diseases
Caregivers
Child, Preschool
symptomatic
Female
Original Article
medicine.symptom
business
Viral load
Brazil
Subjects
Details
- ISSN :
- 17502640
- Volume :
- 12
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Influenza and Other Respiratory Viruses
- Accession number :
- edsair.doi.dedup.....0726eb3e50e50d9c5e6347e871e86e79
- Full Text :
- https://doi.org/10.1111/irv.12518