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Long-term adjuvant imatinib treatment for a patient who underwent complete resection of a localized recurrent gastrointestinal stromal tumor after preoperative imatinib treatment: A case report
- Source :
- Medicine
- Publication Year :
- 2019
-
Abstract
- Rationale: The efficiency and tolerance of long-term adjuvant imatinib treatment for patient who underwent complete resection of a localized recurrent gastrointestinal stromal tumor (GIST) was unknown. Patient concerns: A 45-year-old man underwent complete resection of an intestinal GIST in August 2001. Four years later, a giant (11 × 8 × 6 cm) recurrent GIST located in the retroperitoneum was detected. Diagnosis: The recurrent tumor was positive for CD117 by immunohistochemistry. Interventions: The recurrent tumor was completely resected after 4 months of effective imatinib treatment (400 mg/day), and the patient continued imatinib treatment postoperatively. In June 2011, imatinib treatment was stopped for 3 weeks because of hepatitis B infection, and resumed with a reduced dose level of 300 mg/day when liver function recovered. In March 2017, imatinib treatment was interrupted again for 12 days because the patient underwent cholecystectomy. Outcomes: In December 2017, a computed tomography scan showed no signs of tumor recurrence. To date, the patient has been under adjuvant imatinib treatment for >12 years without severe side effects. The plasma concentration of imatinib (detected in February 2018) was trough concentration (Cmin) 1015.7 ng/mL and peak concentration (Cmax) 1550.5 ng/mL. Lessons: This case report highlights the active role of long-term (>12 years) imatinib treatment after complete resection of localized recurrent GIST.
- Subjects :
- Male
medicine.medical_specialty
Gastrointestinal Stromal Tumors
medicine.medical_treatment
Antineoplastic Agents
Complete resection
Imatinib treatment
gastrointestinal stromal tumor
surgery
03 medical and health sciences
0302 clinical medicine
Neoplasm Recurrence
Text mining
recurrent
medicine
Humans
long-term treatment
030212 general & internal medicine
Clinical Case Report
neoplasms
Chemotherapy
GiST
business.industry
General Medicine
Middle Aged
digestive system diseases
Surgery
imatinib
Chemotherapy, Adjuvant
030220 oncology & carcinogenesis
Imatinib Mesylate
Recurrent Gastrointestinal Stromal Tumor
Neoplasm Recurrence, Local
business
Adjuvant
Research Article
Subjects
Details
- ISSN :
- 15365964
- Volume :
- 98
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....072d250601d37c043fc517bf3e586097