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Glucose homeostasis in GHD children during long-term replacement therapy: a case-control study
- Publication Year :
- 2018
-
Abstract
- PURPOSE: To evaluate glucose homeostasis in children with growth hormone (GH) deficiency (GHD) receiving long-term replacement therapy. METHODS: We evaluated glucose, insulin, HOmeostasis Model Assessment (HOMA-IR), and HbA1c in 100 GHD children at diagnosis and during 5 years of therapy. One hundred healthy children comparable to patients were evaluated at baseline and after 1 and 5 years. RESULTS: No difference was detected at baseline between GHD patients and controls in glucose (79.58 ± 9.96 vs. 77.18 ± 8.20 mg/dl), insulin (4.50 ± 3.24 vs. 4.30 ± 2.60 µU/ml), HbA1c (5.20 ± 0.31 vs. 5.25 ± 0.33%) levels, and HOMA-IR (0.93 ± 0.72 vs. 0.86 ± 0.61). One year of GH was associated with a significant increase in insulin (7.21 ± 4.84, p
- Subjects :
- Blood Glucose
Male
0301 basic medicine
medicine.medical_specialty
Adolescent
Hormone Replacement Therapy
medicine.medical_treatment
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Growth hormone
Growth hormone deficiency
03 medical and health sciences
0302 clinical medicine
Endocrinology
Diabetes mellitus
Internal medicine
medicine
GH replacement therapy
Homeostasis
Humans
Glucose homeostasis
Child
Dwarfism, Pituitary
Glucose homeostasi
Human Growth Hormone
business.industry
Insulin
Insulin sensitivity
Case-control study
medicine.disease
030104 developmental biology
Case-Control Studies
Child, Preschool
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....073318d2d91ca7985c00361be75aa979