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Age- and sex-dependent changes of resting amygdalar activity in individuals free of clinical cardiovascular disease
- Source :
- Journal of Nuclear Cardiology. 28:427-432
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Purpose Amygdalar metabolic activity was shown to independently predict cardiovascular outcomes. However, little is known about age- and sex-dependent variability in neuronal stress responses among individuals free of cardiac disease. This study sought to assess age- and sex-specific differences of resting amygdalar metabolic activity in the absence of clinical cardiovascular disease. Methods Amygdalar metabolic activity was assessed in 563 patients who underwent multimodality imaging by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography and echocardiography for the evaluation of cardiac function. Results After exclusion of 294 patients with structural or functional cardiovascular pathologies, 269 patients (128 women) remained in the final population. 18F-FDG amygdalar activity significantly decreased with age in men (r = − 0.278, P = 0.001), but not in women (r = 0.002, P = 0.983). Similarly, dichotomous analysis confirmed a lower amygdalar activity in men ≥ 50 years as compared to those P = 0.007), which was not observed in women (0.81 ± 0.1 vs. 0.82 ± 0.1, P = 0.549). Accordingly, a fully adjusted linear regression analysis identified age as an independent predictor of amygdalar activity only in men (B-coefficient − 0.278, P = 0.001). Conclusion Amygdalar activity decreases with age in men, but not in women. The use of amygdalar activity for cardiovascular risk stratification merits consideration of inherent age- and sex-dependent variability.
- Subjects :
- Adult
Male
Cardiac function curve
medicine.medical_specialty
Population
610 Medicine & health
Disease
030204 cardiovascular system & hematology
Age and sex
Amygdala
2705 Cardiology and Cardiovascular Medicine
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
Positron Emission Tomography Computed Tomography
Internal medicine
2741 Radiology, Nuclear Medicine and Imaging
Humans
Medicine
Radiology, Nuclear Medicine and imaging
030212 general & internal medicine
education
Aged
Sex Characteristics
education.field_of_study
medicine.diagnostic_test
business.industry
Age Factors
10181 Clinic for Nuclear Medicine
Middle Aged
medicine.anatomical_structure
Cardiovascular Diseases
Heart Disease Risk Factors
Positron emission tomography
Risk stratification
10209 Clinic for Cardiology
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Cardiovascular outcomes
Subjects
Details
- ISSN :
- 15326551 and 10713581
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Journal of Nuclear Cardiology
- Accession number :
- edsair.doi.dedup.....07374e83cfa9d4118675ff6d34571f66
- Full Text :
- https://doi.org/10.1007/s12350-020-02504-7