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Age- and sex-dependent changes of resting amygdalar activity in individuals free of clinical cardiovascular disease

Authors :
Catherine Gebhard
Muriel Grämer
Aju P. Pazhenkottil
Susan Bengs
Dominik Etter
Anna Luisa Beeler
Gioia Epprecht
Atanas Todorov
Angela Portmann
Geoffrey Warnock
Winandus J Wijnen
Ahmed Haider
Felix C. Tanner
Valerie Treyer
Tobias A. Fuchs
Philipp A. Kaufmann
Ronny R. Buechel
Flavia Diggelmann
Michael Fiechter
University of Zurich
Fiechter, Michael
Source :
Journal of Nuclear Cardiology. 28:427-432
Publication Year :
2021
Publisher :
Springer Science and Business Media LLC, 2021.

Abstract

Purpose Amygdalar metabolic activity was shown to independently predict cardiovascular outcomes. However, little is known about age- and sex-dependent variability in neuronal stress responses among individuals free of cardiac disease. This study sought to assess age- and sex-specific differences of resting amygdalar metabolic activity in the absence of clinical cardiovascular disease. Methods Amygdalar metabolic activity was assessed in 563 patients who underwent multimodality imaging by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography and echocardiography for the evaluation of cardiac function. Results After exclusion of 294 patients with structural or functional cardiovascular pathologies, 269 patients (128 women) remained in the final population. 18F-FDG amygdalar activity significantly decreased with age in men (r = − 0.278, P = 0.001), but not in women (r = 0.002, P = 0.983). Similarly, dichotomous analysis confirmed a lower amygdalar activity in men ≥ 50 years as compared to those P = 0.007), which was not observed in women (0.81 ± 0.1 vs. 0.82 ± 0.1, P = 0.549). Accordingly, a fully adjusted linear regression analysis identified age as an independent predictor of amygdalar activity only in men (B-coefficient − 0.278, P = 0.001). Conclusion Amygdalar activity decreases with age in men, but not in women. The use of amygdalar activity for cardiovascular risk stratification merits consideration of inherent age- and sex-dependent variability.

Details

ISSN :
15326551 and 10713581
Volume :
28
Database :
OpenAIRE
Journal :
Journal of Nuclear Cardiology
Accession number :
edsair.doi.dedup.....07374e83cfa9d4118675ff6d34571f66
Full Text :
https://doi.org/10.1007/s12350-020-02504-7