Successful Outcome Of Pregnancy In A Patient With Generalized Lipoatrophic Diabetes Mellitus

Objective To report the first known case of a successful outcome of pregnancy in a patient with generalized lipoatrophic diabetes. Methods We present a detailed case report of a patient who achieved and successfully completed a pregnancy despite having lipoatrophic diabetes. Results With careful attention to glycemic control with use of U-500 insulin and strict avoidance of dietary fat, a 23-year-old woman with lipoatrophic diabetes maintained a pregnancy to 28 weeks. The infant weighed 1,235 g and was devoid of serious metabolic complications. Three months after childbirth, the patient died of gastrointestinal bleeding. Conclusion We are not aware of any previously published report of a successful pregnancy in a patient with generalized, acquired lipoatrophic diabetes. Because of the involvement of multiple organ systems in generalized lipoatrophic diabetes, female patients should be thoroughly advised of the serious pregnancy-associated risks to both the mother and the fetus and the need for extremely close monitoring. (Endocr Pract. 2000;6:34-36)