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Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System

Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System

Authors :
Abraham Nyska
Takanori Harada
David E. Malarkey
Dai Nakae
Bhanu Singh
Michael P. Vinlove
Colin G. Rousseaux
Richard Gregson
Jerrold M. Ward
Thomas Nolte
Fiorella Belpoggi
Bob Thoolen
Wolfgang Kaufmann
Amy E. Brix
Ulrich Deschl
Robert R. Maronpot
Karin Küttler
Source :
Toxicologic Pathology. 38:5S-81S
Publication Year :
2010
Publisher :
SAGE Publications, 2010.

Abstract

The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally-accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and differential diagnosis for classifying microscopic lesions observed in the hepatobiliary system of laboratory rats and mice, with color microphotographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available for society members electronically on the internet (http://goreni.org). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for lesions of the hepatobiliary system in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

Details

ISSN :
15331601 and 01926233
Volume :
38
Database :
OpenAIRE
Journal :
Toxicologic Pathology
Accession number :
edsair.doi.dedup.....075f7bf6475341eb0f08378605631638
Full Text :
https://doi.org/10.1177/0192623310386499