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Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
- Source :
- Nature Communications, 10(1):376. Nature Publishing Group, Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019), Nature Communications, Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.376. ⟨10.1038/s41467-018-08008-w⟩, Kilpeläinen, T O, Bentley, A R & Loos, R J F 2019, ' Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity ', Nature Communications, vol. 10, no. 1, 376 . https://doi.org/10.1038/s41467-018-08008-w, Kilpeläinen, T O, Bentley, A R, Noordam, R, Sung, Y J, Schwander, K, Winkler, T W, Jakupović, H, Chasman, D I, Manning, A, Ntalla, I, Aschard, H, Brown, M R, de las Fuentes, L, Franceschini, N, Guo, X, Vojinovic, D, Aslibekyan, S, Feitosa, M F, Kho, M, Musani, S K, Richard, M, Wang, H, Wang, Z, Bartz, T M, Bielak, L F, Campbell, A, Dorajoo, R, Fisher, V, Hartwig, F P, Horimoto, A R V R, Li, C, Lohman, K K, Marten, J, Sim, X, Smith, A V, Tajuddin, S M, Alver, M, Amini, M, Boissel, M, Chai, J F, Chen, X, Divers, J, Evangelou, E, Gao, C, Graff, M, Harris, S E, He, M, Hsu, F C, Zhao, J H, Loos, R J F, LifeLines Cohort Study & V Varga, T 2019, ' Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity ', Nature Communications, vol. 10, 376 . https://doi.org/10.1038/s41467-018-08008-w, Kilpeläinen, T O, Bentley, A R, Noordam, R, Sung, Y J, Schwander, K, Winkler, T W, Jakupović, H, Chasman, D I, Manning, A, Ntalla, I, Aschard, H, Brown, M R, de las Fuentes, L, Franceschini, N, Guo, X, Vojinovic, D, Aslibekyan, S, Feitosa, M F, Kho, M, Musani, S K, Richard, M, Wang, H, Wang, Z, Bartz, T M, Bielak, L F, Campbell, A, Dorajoo, R, Fisher, V, Hartwig, F P, Horimoto, A R V R, Li, C, Lohman, K K, Marten, J, Sim, X, Smith, A V, Tajuddin, S M, Alver, M, Amini, M, Boissel, M, Chai, J F, Chen, X, Divers, J, Evangelou, E, Gao, C, Graff, M, Harris, S E, He, M, Milaneschi, Y, Yuan, J-M, Penninx, B W J H, Lifelines Cohort Study, Weir, D R, Franks, P W, Rotter, J I, Kooperberg, C B, Gauderman, W J, Psaty, B M, Rice, K M, Munroe, P B, Fornage, M, Cupples, L A, Rotimi, C N, Morrison, A C, Rao, D C & Loos, R J F 2019, ' Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity ', Nature Communications, vol. 10, no. 1, 376 . https://doi.org/10.1038/s41467-018-08008-w, Nature Communications, 10, Nature Communications, 10:376. Nature Publishing Group, Nature Communications, 2019, 10 (1), pp.376. ⟨10.1038/s41467-018-08008-w⟩, Nat. Commun. 10:376 (2019), Nature communications, vol. 10, no. 1, pp. 376
- Publication Year :
- 2018
- Publisher :
- Nature Research (part of Springer Nature), 2018.
-
Abstract
- Publisher's version (útgefin grein)<br />Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.<br />The present work was largely supported by a grant from the US National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (R01HL118305). The full list of acknowledgments appears in the Supplementary Notes 3 and 4.
- Subjects :
- Genetics and Molecular Biology (all)
Male
Genome-wide association study
02 engineering and technology
Biochemistry
MESH: Genotype
MESH: Nerve Tissue Proteins
lcsh:Science
MESH: Lipid Metabolism
Aged, 80 and over
[STAT.AP]Statistics [stat]/Applications [stat.AP]
MESH: Middle Aged
MESH: Asian Continental Ancestry Group
Kólesteról
Hispanic or Latino
MESH: Transcription Factors
MESH: European Continental Ancestry Group
Lipids
ddc
3. Good health
REVEAL
Cholesterol
MESH: Young Adult
Science & Technology - Other Topics
MESH: Membrane Proteins
MESH: Cholesterol, HDL
Hispanic Americans
0210 nano-technology
Erfðarannsóknir
MESH: Cholesterol, LDL
MESH: Triglycerides
Genotype
Genetic Loci
Lipid Metabolism
Science
European Continental Ancestry Group
LIM-Homeodomain Proteins
Locus (genetics)
EXERCISE
Adolescent
Adult
African Continental Ancestry Group/genetics
Aged
Asian Continental Ancestry Group/genetics
Brazil
Calcium-Binding Proteins/genetics
Cholesterol/blood
Cholesterol, HDL/blood
Cholesterol, HDL/genetics
Cholesterol, LDL/blood
Cholesterol, LDL/genetics
European Continental Ancestry Group/genetics
Exercise
Female
Genetic Loci/genetics
Genome-Wide Association Study
Hispanic Americans/genetics
Humans
LIM-Homeodomain Proteins/genetics
Lipid Metabolism/genetics
Lipids/blood
Lipids/genetics
Membrane Proteins/genetics
Microtubule-Associated Proteins/genetics
Middle Aged
Muscle Proteins/genetics
Nerve Tissue Proteins/genetics
Transcription Factors/genetics
Triglycerides/blood
Triglycerides/genetics
Young Adult
General Biochemistry, Genetics and Molecular Biology
Article
White People
CARBOXYLASE
03 medical and health sciences
Physics and Astronomy (all)
MESH: Muscle Proteins
Asian People
Lifelines Cohort Study
SNP
METAANALYSIS
Ancestry
MESH: Adolescent
Biochemistry, Genetics and Molecular Biology (all)
MESH: Humans
Science & Technology
Calcium-Binding Proteins
MESH: Adult
MESH: Microtubule-Associated Proteins
030104 developmental biology
chemistry
MESH: Genome-Wide Association Study
lcsh:Q
MESH: African Continental Ancestry Group
Chemistry (all)
[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM]
MESH: Brazil
MESH: Female
Transcription Factors
0301 basic medicine
General Physics and Astronomy
Blood lipids
Muscle Proteins
MESH: Calcium-Binding Proteins
chemistry.chemical_compound
MESH: Aged, 80 and over
MESH: Cholesterol
WIDE ASSOCIATION
African Continental Ancestry Group
Genetics
MESH: Aged
Multidisciplinary
Public Health, Global Health, Social Medicine and Epidemiology
021001 nanoscience & nanotechnology
Multidisciplinary Sciences
lipids (amino acids, peptides, and proteins)
Medical Genetics
[STAT.ME]Statistics [stat]/Methodology [stat.ME]
Microtubule-Associated Proteins
Asian Continental Ancestry Group
Black People
Nerve Tissue Proteins
Biology
MESH: Genetic Loci
MD Multidisciplinary
Triglycerides
Medicinsk genetik
MESH: LIM-Homeodomain Proteins
Triglyceride
MESH: Hispanic Americans
Cholesterol, HDL
Genome-wide analyses
Membrane Proteins
Lipid metabolism
General Chemistry
Cholesterol, LDL
Arfgengi
MESH: Lipids
MESH: Male
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
INDIVIDUALS
[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics
MESH: Exercise
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Database :
- OpenAIRE
- Journal :
- Nature Communications, 10(1):376. Nature Publishing Group, Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019), Nature Communications, Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.376. ⟨10.1038/s41467-018-08008-w⟩, Kilpeläinen, T O, Bentley, A R & Loos, R J F 2019, ' Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity ', Nature Communications, vol. 10, no. 1, 376 . https://doi.org/10.1038/s41467-018-08008-w, Kilpeläinen, T O, Bentley, A R, Noordam, R, Sung, Y J, Schwander, K, Winkler, T W, Jakupović, H, Chasman, D I, Manning, A, Ntalla, I, Aschard, H, Brown, M R, de las Fuentes, L, Franceschini, N, Guo, X, Vojinovic, D, Aslibekyan, S, Feitosa, M F, Kho, M, Musani, S K, Richard, M, Wang, H, Wang, Z, Bartz, T M, Bielak, L F, Campbell, A, Dorajoo, R, Fisher, V, Hartwig, F P, Horimoto, A R V R, Li, C, Lohman, K K, Marten, J, Sim, X, Smith, A V, Tajuddin, S M, Alver, M, Amini, M, Boissel, M, Chai, J F, Chen, X, Divers, J, Evangelou, E, Gao, C, Graff, M, Harris, S E, He, M, Hsu, F C, Zhao, J H, Loos, R J F, LifeLines Cohort Study & V Varga, T 2019, ' Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity ', Nature Communications, vol. 10, 376 . https://doi.org/10.1038/s41467-018-08008-w, Kilpeläinen, T O, Bentley, A R, Noordam, R, Sung, Y J, Schwander, K, Winkler, T W, Jakupović, H, Chasman, D I, Manning, A, Ntalla, I, Aschard, H, Brown, M R, de las Fuentes, L, Franceschini, N, Guo, X, Vojinovic, D, Aslibekyan, S, Feitosa, M F, Kho, M, Musani, S K, Richard, M, Wang, H, Wang, Z, Bartz, T M, Bielak, L F, Campbell, A, Dorajoo, R, Fisher, V, Hartwig, F P, Horimoto, A R V R, Li, C, Lohman, K K, Marten, J, Sim, X, Smith, A V, Tajuddin, S M, Alver, M, Amini, M, Boissel, M, Chai, J F, Chen, X, Divers, J, Evangelou, E, Gao, C, Graff, M, Harris, S E, He, M, Milaneschi, Y, Yuan, J-M, Penninx, B W J H, Lifelines Cohort Study, Weir, D R, Franks, P W, Rotter, J I, Kooperberg, C B, Gauderman, W J, Psaty, B M, Rice, K M, Munroe, P B, Fornage, M, Cupples, L A, Rotimi, C N, Morrison, A C, Rao, D C & Loos, R J F 2019, ' Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity ', Nature Communications, vol. 10, no. 1, 376 . https://doi.org/10.1038/s41467-018-08008-w, Nature Communications, 10, Nature Communications, 10:376. Nature Publishing Group, Nature Communications, 2019, 10 (1), pp.376. ⟨10.1038/s41467-018-08008-w⟩, Nat. Commun. 10:376 (2019), Nature communications, vol. 10, no. 1, pp. 376
- Accession number :
- edsair.doi.dedup.....0762057e28a365b8dbed4f0bf77d1b25