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Diminished Antioxidant Activity of High-Density Lipoprotein-Associated Proteins in Chronic Kidney Disease
- Source :
- Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
- Publication Year :
- 2013
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2013.
-
Abstract
- Background Decreased serum arylesterase activity, catalyzed by the high-density lipoprotein–associated paraoxonase (PON)-1, is associated with increased oxidant stress and atherosclerosis risk. We sought to determine the prognostic value of serum PON-1 activity, as monitored by PON or arylesterase activities, in subjects with chronic kidney disease (CKD), particularly in relation to established cardiac biomarkers. Methods and Results Serum arylesterase and PON activities were measured in sequential subjects with CKD (n=630; estimated glomerular filtration rate [eGFR]
- Subjects :
- Male
Myocardial Infarction
030232 urology & nephrology
Kaplan-Meier Estimate
030204 cardiovascular system & hematology
outcomes
Gastroenterology
Antioxidants
Arylesterase
chemistry.chemical_compound
0302 clinical medicine
High-density lipoprotein
Interquartile range
Coronary Heart Disease
Medicine
Prospective Studies
Myocardial infarction
Original Research
Aged, 80 and over
biology
Hazard ratio
Middle Aged
3. Good health
Stroke
Cardiovascular Diseases
Female
Lipoproteins, HDL
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
HDL
Renal function
03 medical and health sciences
Internal medicine
Humans
Renal Insufficiency, Chronic
paraoxonase‐1
Aged
Dyslipidemias
Enzyme Assays
Proportional Hazards Models
oxidant stress
Aryldialkylphosphatase
arylesterase
business.industry
Paraoxonase
medicine.disease
Oxidative Stress
Endocrinology
chemistry
Case-Control Studies
biology.protein
business
chronic kidney disease
Follow-Up Studies
Kidney disease
Subjects
Details
- ISSN :
- 20479980
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of the American Heart Association
- Accession number :
- edsair.doi.dedup.....0762706a6a81645f6be1b605343099be