A review of glyphosate application: the health-related effect

Rog Joanna, Wróbel-Knybel Paulina. A review of glyphosate application: the health-related effect. Journal of Education, Health and Sport. 2019;9(9):804-815. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3460377 http://ojs.ukw.edu.pl/index.php/johs/article/view/7504 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 25.08.2019. Revised: 31.08.2019. Accepted: 22.09.2019. A review of glyphosate application: the health-related effect Joanna Rog, Paulina Wróbel-Knybel Joanna Rog1 ORCID: https://orcid.org/0000-0003-4057-9507 mail: rog.joann@gmail.com; Paulina Wróbel-Knybel1 ORCID: https://orcid.org/0000-0002-4741-5911 mail: polinkawrobel@interia.pl 1 1st Department of Psychiatry, Psychotherapy and Early Intervention, Medical University of Lublin, Poland, Głuska 1 Street, 20-439 Lublin Abstract Introduction and purpose The glyphosate (GLY) is a systemic herbicide and crop desiccant registered for use in more than 130 countries. The herbicide is applied to control more than 160 weeds. Despite the declarations about complete biodegradability of herbicide, is difficult to complete elimination of it. GLY may affect the activity of cytochrome P450, the gut microbiome and metals chelation and thus have an adverse health effect. The evidence suggests a relationship between the use of GLY and numerous chronic diseases. The aim of this paper was to review the available literature that examined the health-related effect of GLY. The state of knowledge Numerous studies have confirmed the adverse effects of GLY on health. GLY injection in high dose initiate processes involved in cancerogenesis. In human studies, the GLY use was related with 41% higher risk of non-Hodgkin's lymphoma. GLY can lead to endocrine changes, including corticosterone levels and steroidogenesis. In pregnant women population, the higher GLY concentrations in urine were related with shorter pregnancy length. GLY could affects gut microbiome and leading to the development of intestinal dysbiosis, gut-brain axis and central nervous system changes. The formulated complexes GLY-minerals may damage nephrons. The nephrotoxic effect of herbicide was confirmed in human studies. Conclusions Most of the studies assessed the short term health-related effect of GLY. Obtained results do not reflect the environmental exposure which lasting many years. There is an urgent need to assess the long term effect of GLY in small doses in high-quality epidemiological studies. Keywords: Glyphosate; Roundup; Cancerogenesis, Microbial community; Endocrine disruption; Gut-brain axis