Back to Search
Start Over
Oral health and plaque microbial profile in juvenile idiopathic arthritis
- Source :
- Pediatric Rheumatology Online Journal, Pediatric Rheumatology Online Journal, Vol 17, Iss 1, Pp 1-9 (2019)
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Background The oral microbiota has been implicated in the pathogenesis of rheumatoid arthritis through activation of mucosal immunity. This study tested for associations between oral health, microbial communities and juvenile idiopathic arthritis (JIA). Methods A cross-sectional exploratory study of subjects aged 10–18 years with oligoarticular, extended oligoarticular and polyarticular JIA was conducted. Control groups included pediatric dental clinic patients and healthy volunteers. The primary aim was to test for an association between dental health indices and JIA; the secondary aim was to characterize the microbial profile of supragingival plaque using 16S rRNA gene sequencing. Results The study included 85 patients with JIA, 62 dental patients and 11 healthy child controls. JIA patients overall had significantly more gingival inflammation compared to dental patients, as evidenced by bleeding on probing of the gingiva, the most specific sign of active inflammation (p = 0.02). Overall, however, there was a trend towards better dental hygiene in the JIA patients compared to dental patients, based on indices for plaque, decay, and periodontitis. In the JIA patients, plaque microbiota analysis revealed bacteria belonging to genera Haemophilus or Kingella elevated, and Corynebacterium underrepresented. In poly JIA, bacteria belonging to the genus Porphyromonas was overrepresented and Prevotella was underrepresented. Conclusion Increased gingival inflammation in JIA was independent of general oral health, and thus cannot be attributed to poor dental hygiene secondary to disability. The variation of microbial profile in JIA patients could indicate a possible link between gingivitis and synovial inflammation.
- Subjects :
- Male
0301 basic medicine
lcsh:Diseases of the musculoskeletal system
genetic structures
Arthritis
Pathogenesis
Gingivitis
0302 clinical medicine
RNA, Ribosomal, 16S
Prevotella
Immunology and Allergy
Child
skin and connective tissue diseases
biology
Microbiota
lcsh:RJ1-570
3. Good health
Rheumatoid arthritis
Female
medicine.symptom
Research Article
musculoskeletal diseases
medicine.medical_specialty
Oral health
Adolescent
Bleeding on probing
Dental Plaque
03 medical and health sciences
Rheumatology
Internal medicine
medicine
Humans
Periodontitis
Mouth
business.industry
lcsh:Pediatrics
030206 dentistry
Juvenile idiopathic arthritis
medicine.disease
biology.organism_classification
Arthritis, Juvenile
stomatognathic diseases
Cross-Sectional Studies
030104 developmental biology
Case-Control Studies
Pediatrics, Perinatology and Child Health
lcsh:RC925-935
business
Subjects
Details
- ISSN :
- 15460096
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Pediatric Rheumatology
- Accession number :
- edsair.doi.dedup.....079002aa0c4d006b92ed4caf6562309d
- Full Text :
- https://doi.org/10.1186/s12969-019-0387-5