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The study of vancomycin use and its adverse reactions associated to patients of a brazilian university hospital

Authors :
Lucio Mendes Cabral
Carlos Rangel Rodrigues
Gisele Huf
Valeria Pereira de Sousa
Helena Carla Castro
Daniel Savignon Marinho
Bruno Leal Alves Ferreira
Source :
BMC Research Notes, BMC Research Notes, Vol 4, Iss 1, p 236 (2011)
Publication Year :
2011
Publisher :
Springer Science and Business Media LLC, 2011.

Abstract

Background Vancomycin is an antibiotic of growing importance in the treatment of hospital infections, with particular emphasis on its value in the fight against methicillin-resistant Staphylococcus aureus. However its usage profile must be evaluated to assure maximum benefit and minimum risk. Findings A cross-sectional retrospective study was carried out among inpatients that received vancomycin in a Brazilian quaternary hospital. The occurrence of adverse reactions reported was evaluated in medical records relating to patients taking vancomycin during a one year period. Males comprised 52% (95% CI: 41.7-60.2%) of the sample population, with a mean age of 50.6 (95% CI: 47.2-54.0) years and mean treatment period of 9.7 (95% CI: 8.0-11.5) Days. It was verified that nephrotoxicity occurred in 18.4% (95% CI: 11.3-27.5) of patients, Red man syndrome occurred in 2% (95% CI 0.2-7.2), while the occurrence of thrombocytopenia was 7.1% (95% CI: 2.9-14.2). Conclusions It may be noted that even after 50 years of use, adverse reactions associated with vancomycin continue with high frequency, presenting a public health problem, especially considering its current use in cases of multidrug resistant infections. In this context, we emphasize the importance of intensive pharmacovigilance in hospital as a surveillance tool after drug approval by the sanitary authority.

Details

ISSN :
17560500
Volume :
4
Database :
OpenAIRE
Journal :
BMC Research Notes
Accession number :
edsair.doi.dedup.....079326559c20ddd2bdb1d4c2f2e724db
Full Text :
https://doi.org/10.1186/1756-0500-4-236