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PtrA is a periplasmic protein involved in Cu tolerance in Pseudomonas aeruginosa

Authors :
Michel Ragno
Ina Attree
Sylvie Elsen
Biologie du Cancer et de l'Infection (BCI )
Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG)
Direction de Recherche Fondamentale (CEA) (DRF (CEA))
Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA))
Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)
Pathogénie bactérienne et réponses cellulaires
Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)
Source :
Journal of Bacteriology, Journal of Bacteriology, American Society for Microbiology, 2011, 193 (13), pp.3376-8. ⟨10.1128/JB.00159-11⟩, Journal of Bacteriology, 2011, 193 (13), pp.3376-8. ⟨10.1128/JB.00159-11⟩
Publication Year :
2011
Publisher :
HAL CCSD, 2011.

Abstract

In this work, we demonstrate that PtrA (U. H. Ha et al., Mol. Microbiol. 54:307–320, 2004) is a periplasmic protein, specifically synthesized in the presence of copper, that is involved in the tolerance of Pseudomonas aeruginosa to copper. Our biochemical and genetic analyses challenge its role in transcriptional inhibition of the type III secretion system.

Subjects

Subjects :
Transcription, Genetic
chemistry.chemical_element
medicine.disease_cause
Microbiology
Type three secretion system
Periplasmic Proteins
03 medical and health sciences
Bacterial Proteins
Drug Resistance, Bacterial
MESH: Drug Resistance, Bacterial
medicine
Molecular Biology
MESH: Bacterial Proteins
030304 developmental biology
Molecular Biology of Pathogens
0303 health sciences
MESH: Gene Expression Regulation, Bacterial
biology
030306 microbiology
Pseudomonas aeruginosa
MESH: Transcription, Genetic
Gene Expression Regulation, Bacterial
Periplasmic space
biology.organism_classification
Copper
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
MESH: Copper
Biochemistry
chemistry
Pseudomonadales
MESH: Pseudomonas aeruginosa
Bacteria
Pseudomonadaceae
MESH: Periplasmic Proteins

Details

Language :
English
ISSN :
00219193 and 10985530
Database :
OpenAIRE
Journal :
Journal of Bacteriology, Journal of Bacteriology, American Society for Microbiology, 2011, 193 (13), pp.3376-8. ⟨10.1128/JB.00159-11⟩, Journal of Bacteriology, 2011, 193 (13), pp.3376-8. ⟨10.1128/JB.00159-11⟩
Accession number :
edsair.doi.dedup.....0793cc93d97c95792aecf5105db4d863

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