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Short-Term Effects of Parathyroid Hormone on Rat Lumbar Vertebrae
- Source :
- Spine. 34:2014-2021
- Publication Year :
- 2009
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2009.
-
Abstract
- Study Design. This study is an experimental study in the rat osteopenia model. Objective. The aim of this study was to evaluate the short-term effects of daily application of parathyroid hormone (PTH) on bone quality and quantity using a new biomechanical compression test for intact rat lumbar vertebrae. Summary of Background Data. Because of their high clinical relevance, trabecular content and thick cortical shell vertebrae are of high interest for osteoporosis research. Biomechanical stability depends on both trabecular and cortical bone. Anabolic effects on bone after long-term application of PTH have already been proven. Methods. After an intraindividual comparison (n = 20), the capability of a new test to identify biomechanical properties of the mature rat model was assessed. In the following, 33 three-month-old rats were ovariectomized. After 10 weeks, the animals were divided into 3 groups. The control group (C) received no additional food supplementation. The other groups received hormone treatment with either estradiol (E) or PTH for another 5 weeks. The effects on bone biomechanical properties and bone microstructure were analyzed. Results. After establishing the new biomechanical test for intact rat lumbar vertebrae, PTH-treated (yield stress: 2.95 N/mm 3 , elastic limit: 2.39 N/mm 3 ) and then E-treated (yield stress: 2.13 N/mm 3 , elastic limit: 1.68 N/mm 3 ) animals showed superior biomechanical results. Compression strength was significantly improved in these rats in comparison to the control group rats (yield stress: 1.86 N/mm 3 , elastic limit: 1.38 N/mm 3 ). In the microradiographic evaluation, PTH significantly improved the morphologic results to produce thicker trabeculae. E led to a more densely branched trabecular network, which was not as important as trabecular thickness for bone stability. Conclusion. After a short-term application, PTH is superior to E in recreating bone biomechanical properties and lumbar vertebral microstructure in advanced osteoporosis. The cortical shell and trabecular thickness are primarily responsible for the biomechanical strength of vertebrae.
- Subjects :
- medicine.medical_specialty
Time Factors
Compressive Strength
Anabolism
Injections, Subcutaneous
Ovariectomy
Osteocalcin
Osteoporosis
Administration, Oral
Parathyroid hormone
030209 endocrinology & metabolism
Lumbar vertebrae
Rats, Sprague-Dawley
03 medical and health sciences
0302 clinical medicine
Lumbar
Internal medicine
medicine
Animals
Orthopedics and Sports Medicine
030304 developmental biology
0303 health sciences
Lumbar Vertebrae
Bone Density Conservation Agents
Estradiol
business.industry
Estrogen Replacement Therapy
Anatomy
medicine.disease
Microradiography
Biomechanical Phenomena
Rats
3. Good health
Osteopenia
Disease Models, Animal
medicine.anatomical_structure
Endocrinology
Parathyroid Hormone
Ovariectomized rat
Female
Cortical bone
Bone Remodeling
Neurology (clinical)
business
Biomarkers
Subjects
Details
- ISSN :
- 03622436
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Spine
- Accession number :
- edsair.doi.dedup.....07ade445e479ece3f6341616ceeb918f