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Current knowledge about the impact of microgravity on the proteome
- Source :
- Strauch, S M, Grimm, D, Corydon, T J, Krüger, M, Bauer, J, Lebert, M, Wise, P, Infanger, M & Richter, P 2019, ' Current Knowledge about the Impact of Microgravity on the Proteome ', Expert Review of Proteomics, vol. 16, no. 1, pp. 5-16 . https://doi.org/10.1080/14789450.2019.1550362
- Publication Year :
- 2018
-
Abstract
- Introduction: Microgravity (µg) is an extreme stressor for plants, animals, and humans and influences biological systems. Humans in space experience various health problems during and after a long-term stay in orbit. Various studies have demonstrated structural alterations and molecular biological changes within the cellular milieu of plants, bacteria, microorganisms, animals, and cells. These data were obtained by proteomics investigations applied in gravitational biology to elucidate changes in the proteome occurring when cells or organisms were exposed to real µg (r-µg) and simulated µg (s-µg). Areas covered: In this review, we summarize the current knowledge about the impact of µg on the proteome in plants, animals, and human cells. The literature suggests that µg impacts the proteome and thus various biological processes such as angiogenesis, apoptosis, cell adhesion, cytoskeleton, extracellular matrix proteins, migration, proliferation, stress response, and signal transduction. The changes in cellular function depend on the respective cell type. Expert commentary: This data is important for the topics of gravitational biology, tissue engineering, cancer research, and translational regenerative medicine. Moreover, it may provide new ideas for countermeasures to protect the health of future space travelers.
- Subjects :
- 0301 basic medicine
Cell type
030102 biochemistry & molecular biology
Proteome
Tissue Engineering
Weightlessness
Gravitational biology
Biology
Proteomics
Biochemistry
Regenerative medicine
Mass Spectrometry
Cell biology
03 medical and health sciences
030104 developmental biology
Animals
Humans
Signal transduction
Cell adhesion
Molecular Biology
Function (biology)
Subjects
Details
- ISSN :
- 17448387
- Volume :
- 16
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Expert review of proteomics
- Accession number :
- edsair.doi.dedup.....07bd11bbdfef948120abbf9704c90d81