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A controlled trial of daily versus thrice-weekly buprenorphine administration for the treatment of opioid dependence
A controlled trial of daily versus thrice-weekly buprenorphine administration for the treatment of opioid dependence
- Source :
- Drug and alcohol dependence. 59(3)
- Publication Year :
- 2000
-
Abstract
- This study was aimed at determining whether thrice-weekly administration of buprenorphine is as effective as daily administration for treating opioid dependence. A total of 60 treatment-seeking opioid addicts were randomly assigned to take buprenorphine tablets sublingually either every day (8 mg) or thrice-weekly (16 mg on Mondays and Wednesdays and 24 mg on Fridays) over the course of a 12-week, double-blind, parallel trial. The buprenorphine dosing schedule had no significant effect on treatment retention. The rates of opioid-positive urine tests were significantly higher among those subjects who were given buprenorphine thrice weekly (58.5%) than among those who took it daily (46.6%). An analysis of the completers did not detect a significant effect of buprenorphine dosing schedule. The results obtained in our clinical trials indicate the advisability of daily doses of buprenorphine, at least at the beginning of a maintenance programme.
- Subjects :
- Adult
Male
Narcotic Antagonists
Treatment outcome
Treatment retention
Toxicology
Heroin
law.invention
Randomized controlled trial
Double-Blind Method
law
medicine
Humans
Pharmacology (medical)
Dosing
Pharmacology
Analysis of Variance
business.industry
Middle Aged
Opioid-Related Disorders
Buprenorphine
Clinical trial
Behavior, Addictive
Psychiatry and Mental health
Treatment Outcome
Opioid
Anesthesia
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 03768716
- Volume :
- 59
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Drug and alcohol dependence
- Accession number :
- edsair.doi.dedup.....07c880a850e6427e7c12aa759cbbe2dd