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Strong preference for autaptic self-connectivity of neocortical PV interneurons entrains them to γ-oscillations
- Publication Year :
- 2018
- Publisher :
- Cold Spring Harbor Laboratory, 2018.
-
Abstract
- SummaryParvalbumin (PV) positive interneurons modulate cortical activity through highly specialized connectivity patterns onto excitatory pyramidal neurons (PNs) and other inhibitory cells. PV cells are auto-connected through powerful autapses, but the contribution of this form of fast disinhibition to cortical function is unknown. We found that autaptic transmission represents the most powerful input of PV cells in neocortical Layer V. Autaptic strength was greater than synaptic strength onto PNs as result of a larger quantal size, whereas autaptic and heterosynaptic PV-PV synapses differed in the number of release sites. Overall, single-axon autaptic transmission contributed to ~40% of the total perisomatic inhibition that PV interneurons received. The strength of autaptic transmission modulated the coupling of PV-cell firing with optogenetically-induced γ-oscillations preventing high frequency bursts of spikes. Autaptic self-inhibition represents an exceptionally large and fast disinhibitory mechanism to synchronize the output of PV cells during cognitive-relevant cortical network activity.
- Subjects :
- 0303 health sciences
Quantal size
biology
Chemistry
Inhibitory postsynaptic potential
Coupling (electronics)
03 medical and health sciences
0302 clinical medicine
nervous system
Disinhibition
Cortical network
biology.protein
medicine
Excitatory postsynaptic potential
medicine.symptom
Neuroscience
030217 neurology & neurosurgery
Parvalbumin
030304 developmental biology
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....07ce2b1027f3fe4b82f7de798c2a5543