Role of endogenous fatty acids in the control of hepatic gluconeogenesis

Inhibition of endogenous long chain fatty acids oxidation by tetradecylglycidate (TDGA) impeded gluconeogenesis from lactate or from low concentrations of pyruvate (0.5 mM), β-hydroxybutyrate or even ethanol was capable of overcoming the inhibitory effect of TDGA in the absence of significant changes in the hepatic content of acetyl-CoA. At low (
This work has been supported in part by grants from Dirección General de Investigación Científica y Técnica (87065 and PL87-0280), and Fondo de Investigaciones Sanitarias (89/0467 and 89/0468). C. González-Manchón was recipient of a fellowship from Ministerio de Educación y Ciencia.