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SARS‐CoV‐2 Omicron emergence urges for reinforced One‐Health surveillance

Authors :: Xavier Montagutelli
Sylvie van der Werf
Felix A Rey
Etienne Simon‐Loriere
Génétique de la souris - Mouse Genetics
Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité)
Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2))
Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)
Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae [Paris] (CNR - laboratoire coordonnateur)
Institut Pasteur [Paris] (IP)
Virologie Structurale - Structural Virology
Génomique évolutive des virus à ARN - Evolutionary genomics of RNA viruses
This work was supported by the 'URGENCE COVID-19' fundraising campaign of Institut Pasteur), the French Government’s Investissement d’Avenir program, Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases (Grant No. ANR-10-LABX-62-IBEID), the Agence Nationale de la Recherche (Grant No. ANR-20-COVI-0028-01) and the RECOVER project funded by the European Union’s Horizon 2020 research and innovation program under grant agreement No. 101003589. ESL acknowledges funding from the INCEPTION program (Investissements d’Avenir grant ANR-16-CONV-0005)
ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010)
ANR-20-COVI-0028,HuMoCID,Développement de modèles murins de COVID-19(2020)
ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016)
European Project: 101003589, H2020-SC1-PHE-CORONAVIRUS-2020,RECOVER(2020)
Institut Pasteur [Paris]-Université Paris Cité (UPC)
Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPC)
Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae [Paris] (CNR)
Institut Pasteur [Paris]
Source :: EMBO Molecular Medicine, EMBO Molecular Medicine, 2022, 14 (3), pp.e15558. ⟨10.15252/emmm.202115558⟩, EMBO Molecular Medicine, Wiley Open Access, 2022, 14 (3), pp.e15558. ⟨10.15252/emmm.202115558⟩
Publication Year :: 2022
Publisher :: HAL CCSD, 2022.
Abstract: International audience; SARS-CoV-2 Omicron harbors substitutions in the receptor binding domain of the spike which strongly suggest its capacity to infect rodents. Wild animal reservoirs could favor the emergence of new variants with risks of spillback to humans and should be closely monitored

Subjects :: SARS-CoV-2
Population Surveillance
Spike Glycoprotein, Coronavirus
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Molecular Medicine
Animals
COVID-19
Humans
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
One Health
Protein Binding

Details

Language :: English
ISSN :: 17574676 and 17574684
Database :: OpenAIRE
Journal :: EMBO Molecular Medicine, EMBO Molecular Medicine, 2022, 14 (3), pp.e15558. ⟨10.15252/emmm.202115558⟩, EMBO Molecular Medicine, Wiley Open Access, 2022, 14 (3), pp.e15558. ⟨10.15252/emmm.202115558⟩
Accession number :: edsair.doi.dedup.....07f405e8b0072b0a93def9aec2576bec
Full Text :: https://doi.org/10.15252/emmm.202115558⟩