Feasibility of using MgSO4 and a self-designed inspiratory impedance threshold device in cardiac arrest-cardiopulmonary resuscitation study on porcine model

Cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) have always been two research hotpots in emergency medicine. Problems such as optimizing animal CA models and promoting CPR efficiency are to be explored. Establishing animal CA models is the precondition of CPR study. Previous studies usually use electric shock or intravenous drug administration to induce CA in animals. Nevertheless, as electric shock is complicated to operate and the dosage for drug administration is difficult to control, many published animal CA models are not ideally stable and operable. In order to establish a stable and operable CA model for cardiac arrest- cardiopulmonary resuscitation (CA-CPR) research, this study established different pig CA models via intravenous administration of KCI, MgSO 4 and ketamine respectively, and subsequently performed CRP with a self-designed inspiratory impedance threshold device (SIITD). The success rate of CRP in different CA models was evaluated according to hemodynamic and biochemical parameters of pigs. Results demonstrated that in the CA model established by intravenous administration of MgSO 4 , cardiac output of pigs were significantly elevated and reached the normal range at 10-min after CPR, and other vital signs and biochemical parameters in this model exhibited recovery trends throughout CPR. This study provides a more effective CA model and new ideas in methodology of future CA-CPR research.