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Rh(III)-catalyzed directed C–H carbenoid coupling reveals aromatic bisphosphonates inhibiting metallo- and Serine-β-lactamases
- Publication Year :
- 2018
- Publisher :
- Royal Society of Chemistry, 2018.
-
Abstract
- We report the highly efficient and scalable Rh(III)-catalyzed C–H coupling of arenes with diazo-methylene-diphosphonates to give structurally diverse aromatic bisphosphonates in good to excellent yields. These bisphosphonates are one of the very few classes of inhibitors acting against the mechanistically distinct metallo-β-lactamases and serine-β-lactamases and thus represent good starting points for the development of broad spectrum β-lactamase inhibitors.
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....081accf635729a63d5aa63e05d0567d0