Back to Search
Start Over
Expression of the Xist Gene in Urogenital Ridges of Midgestation Male Embryos
- Source :
- Biochemical and Biophysical Research Communications. 205:334-340
- Publication Year :
- 1994
- Publisher :
- Elsevier BV, 1994.
-
Abstract
- We show by RT-PCR analysis that transcripts from the Xist gene, which is normally expressed from the inactive X chromosome of female somatic cells and postnatal male germ cells, are transiently expressed also in male embryos around the time of testis differentiation, mainly in somatic cells of urogenital ridges. In the postnatal testis, we find that Xist transcripts are mainly localized within the nucleus of haploid spermatids. These findings suggest that inactivation of the X-chromosome might occur not only in adult male germ cells, but also, transiently, in somatic cells of the male urogenital ridge. Both in the embryonal gonad and in differentiating germ cells Xist expression in males overlaps the pattern of expression of the testis determining gene Sry.
- Subjects :
- Male
endocrine system
RNA, Untranslated
X Chromosome
Gonad
Somatic cell
Messenger
Molecular Sequence Data
Biophysics
Urogenital System
Gestational Age
Biology
Biochemistry
Mice
medicine
Animals
Developmental
RNA, Messenger
Oligodeoxyribonucleotides
Base Sequence
Transcription Factors
Embryo, Mammalian
Gene Expression Regulation, Developmental
Molecular Biology
Gene
X chromosome
Settore BIO/16
Gonadal ridge
Mammalian
Untranslated
Embryo
Cell Biology
Molecular biology
Cell biology
Testis determining factor
medicine.anatomical_structure
Gene Expression Regulation
RNA
RNA, Long Noncoding
XIST
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 205
- Database :
- OpenAIRE
- Journal :
- Biochemical and Biophysical Research Communications
- Accession number :
- edsair.doi.dedup.....083511f372217e51a33e8cbc9eea4010