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Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno- or squamous cell carcinoma

Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno- or squamous cell carcinoma

Authors :
Ben J.M. Witteman
Rene H. M. te Morsche
Theo Wobbes
Adriaan C.I.T.L. Tan
Jon O. Kristinsson
Hennie M.J. Roelofs
Jan B.M.J. Jansen
Paul van Westerveld
Wilbert H.M. Peters
Martijn G.H. van Oijen
Oncology
Source :
World Journal of Gastroenterology, 15, 28, pp. 3493-7, World Journal of Gastroenterology, 15, 3493-7, World journal of gastroenterology, 15(28), 3493-3497. WJG Press
Publication Year :
2009

Abstract

Contains fulltext : 79521.pdf (Publisher’s version ) (Open Access) AIM: To determine whether -1195 A-->G and/or -765 G-->C polymorphisms in Cyclooxygenase-2 (COX-2) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population. METHODS: Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area. DNA was isolated from whole blood and used for genotyping. PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis. Odds ratios (OR) and 95% confidence intervals (CI) were estimated. RESULTS: The distribution of the -1195 A-->G polymorphism was significantly different in esophageal cancer patients compared to controls. The -1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma (OR = 3.85, 95% CI: 1.45-10.3) compared with the -1195 AA genotype as a reference. The -765 G-->C genotype distribution was not different between the two groups. The GG/GG haplotype was present more often in esophageal adenocarcinoma patients than in controls (OR = 3.45, 95% CI: 1.24-9.58; with AG/AG as a reference). The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical significance. CONCLUSION: Presence of the COX-2 -1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma.

Details

ISSN :
10079327
Database :
OpenAIRE
Journal :
World Journal of Gastroenterology, 15, 28, pp. 3493-7, World Journal of Gastroenterology, 15, 3493-7, World journal of gastroenterology, 15(28), 3493-3497. WJG Press
Accession number :
edsair.doi.dedup.....0852fac3814089d999b1f03fd9866ba0