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Prognostic Significance of mTOR and PTEN in Patients with Esophageal Squamous Cell Carcinoma
- Source :
- BioMed Research International, Vol 2015 (2015), BioMed Research International
- Publication Year :
- 2015
- Publisher :
- Hindawi Limited, 2015.
-
Abstract
- The prognostic value of mTOR in ESCC is much controversial; this study aimed to determine the prognostic importance of mTOR and PTEN in patients with ESCC. A total of 148 consecutive patients who underwent esophagectomy from 2010 to 2012 were included in this study, tested by western bolt and immunohistochemistry for mTOR and PTEN expression. Correlation coefficient was calculated using Pearson’s correlation test. The 3-year overall survival (OS) and disease-free survival (DFS) were calculated in relation to the two markers. 94 (63.5%) of 148 were mTOR high expression, and PTEN high expression was detected in 46 (31.1%) of the 148 patients with ESCC. The Pearson correlation coefficient revealed a significant negative correlation in two proteins (correlation coefficient = −0.189, P<0.005). The 3-year OS and DFS time in the mTOR-high group was 23.9 and 18.4 months, respectively, and the time in the mTOR-low group was 33.9 months and 31.4 months, respectively. The difference of survival rate between the two groups remained statistically significant. mTOR-low or PTEN-high patients had better 3-year rates of OS and DFS than mTOR-high or PTEN-low group (P<0.001 by the log-rank test). This study also found that mTOR was an independence prognostic factor by multivariate analysis.
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Pathology
Article Subject
Esophageal Neoplasms
Correlation coefficient
medicine.medical_treatment
lcsh:Medicine
Biology
Disease-Free Survival
General Biochemistry, Genetics and Molecular Biology
symbols.namesake
Internal medicine
Biomarkers, Tumor
medicine
Carcinoma
Humans
PTEN
Survival rate
PI3K/AKT/mTOR pathway
Aged
Aged, 80 and over
General Immunology and Microbiology
TOR Serine-Threonine Kinases
lcsh:R
PTEN Phosphohydrolase
General Medicine
Middle Aged
Prognosis
medicine.disease
Immunohistochemistry
Pearson product-moment correlation coefficient
Esophagectomy
Survival Rate
Carcinoma, Squamous Cell
biology.protein
symbols
Female
Esophageal Squamous Cell Carcinoma
Research Article
Subjects
Details
- ISSN :
- 23146141 and 23146133
- Volume :
- 2015
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....085ab379eac10c47896fca648404abb4