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Extensive Pituitary Apoplexy after Chemotherapy in a Patient with Metastatic Breast Cancer

Authors :
Eun Kyeong Hong
Young San Ko
Je Hun Jang
Ho Shin Gwak
Source :
Brain Tumor Research and Treatment
Publication Year :
2018
Publisher :
The Korean Brain Tumor Society, The Korean Society for Neuro-Oncology, 2018.

Abstract

Surgery, anticoagulation therapy, pregnancy, and hormone treatments, such as bromocriptine, are well-characterized precipitating factors for pituitary apoplexy. However, whether cytotoxic chemotherapy for systemic cancer could cause pituitary apoplexy has not been investigated. Here, we present a case of a 41-year-old woman who developed a severe headache with decreased visual acuity after intravenous cytotoxic chemotherapy to treat metastatic breast cancer. Preoperative neuroimaging revealed pituitary adenoma with necrosis. Operative findings and pathologic examination concluded extensive necrosis with a small intratumoral hemorrhage in a pre-existing pituitary adenoma. We reviewed two additional previously published cases of pituitary apoplexy after systemic chemotherapy and suggest that cytotoxic chemotherapy may induce pituitary apoplexy.

Details

ISSN :
22882413 and 22882405
Volume :
6
Database :
OpenAIRE
Journal :
Brain Tumor Research and Treatment
Accession number :
edsair.doi.dedup.....088348ba73f39ad75d4530c266eee4c4
Full Text :
https://doi.org/10.14791/btrt.2018.6.e7