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Extensive Pituitary Apoplexy after Chemotherapy in a Patient with Metastatic Breast Cancer
- Source :
- Brain Tumor Research and Treatment
- Publication Year :
- 2018
- Publisher :
- The Korean Brain Tumor Society, The Korean Society for Neuro-Oncology, 2018.
-
Abstract
- Surgery, anticoagulation therapy, pregnancy, and hormone treatments, such as bromocriptine, are well-characterized precipitating factors for pituitary apoplexy. However, whether cytotoxic chemotherapy for systemic cancer could cause pituitary apoplexy has not been investigated. Here, we present a case of a 41-year-old woman who developed a severe headache with decreased visual acuity after intravenous cytotoxic chemotherapy to treat metastatic breast cancer. Preoperative neuroimaging revealed pituitary adenoma with necrosis. Operative findings and pathologic examination concluded extensive necrosis with a small intratumoral hemorrhage in a pre-existing pituitary adenoma. We reviewed two additional previously published cases of pituitary apoplexy after systemic chemotherapy and suggest that cytotoxic chemotherapy may induce pituitary apoplexy.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Case Report
Gastroenterology
Necrosis
03 medical and health sciences
Breast cancer
0302 clinical medicine
Pituitary adenoma
Internal medicine
medicine
Chemotherapy
General Environmental Science
Pregnancy
Pituitary apoplexy
business.industry
Cancer
medicine.disease
Metastatic breast cancer
Bromocriptine
030220 oncology & carcinogenesis
General Earth and Planetary Sciences
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 22882413 and 22882405
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Brain Tumor Research and Treatment
- Accession number :
- edsair.doi.dedup.....088348ba73f39ad75d4530c266eee4c4
- Full Text :
- https://doi.org/10.14791/btrt.2018.6.e7