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Hepatitis delta virus testing, epidemiology and management: A multicentre cross-sectional study of patients in London
- Source :
- Journal of Clinical Virology. :33-37
- Publisher :
- The Authors. Published by Elsevier B.V.
-
Abstract
- Background Hepatitis delta virus (HDV) testing is recommended for all patients with hepatitis B virus (HBV) infection. HDV infection is associated with severe liver disease and interferon is the only available treatment. Objectives To determine the rate of anti-HDV antibody testing in HBV patients; and to describe the epidemiology, clinical characteristics and management of HDV-infected patients at four hospitals in London. Study design The anti-HDV testing rate was estimated by reviewing clinical and laboratory data. Cross-sectional data collection identified HDV-infected patients who had attended the study centres between 2005 and 2012. Results At a centre with clinic-led anti-HDV testing, 40% (67/168) of HBV patients were tested. Recently diagnosed HBV patients were more likely to be screened than those under long-term follow-up (62% vs 36%, P = 0.01). At a centre with reflex laboratory testing, 99.4% (3543/3563) of first hepatitis B surface antigen positive samples were tested for anti-HDV. Across the four study centres there were 55 HDV-infected patients, of whom 50 (91%) had immigrated to the UK and 27 (49%) had evidence of cirrhosis. 31 patients received interferon therapy for HDV with an end of treatment virological response observed in 10 (32%). Conclusions The anti-HDV testing rate was low in a centre with clinic-led testing, but could not be evaluated in all centres. The HDV-infected patients were of diverse ethnicity, with extensive histological evidence of liver disease and poor therapeutic responses. Future recommendations include reflex laboratory testing algorithms and a prospective cohort study to optimise the investigation and management of these patients.
- Subjects :
- Adult
Male
medicine.medical_specialty
Cirrhosis
Cross-sectional study
Epidemiology
viruses
Testing
medicine.disease_cause
Liver disease
Hepatitis B, Chronic
Virology
Internal medicine
HDV
London
medicine
HBV
Humans
Immunologic Factors
Mass Screening
Hepatitis Antibodies
Prospective cohort study
Mass screening
Hepatitis B virus
Diagnostic Tests, Routine
business.industry
virus diseases
Middle Aged
biochemical phenomena, metabolism, and nutrition
medicine.disease
Hepatitis D
Management
Cross-Sectional Studies
Infectious Diseases
Immunology
Female
Health Services Research
Interferons
Hepatitis Delta Virus
business
Subjects
Details
- Language :
- English
- ISSN :
- 13866532
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Virology
- Accession number :
- edsair.doi.dedup.....088e6bd9227dd692bd950e96475907bf
- Full Text :
- https://doi.org/10.1016/j.jcv.2015.02.011