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In-Hospital Safety and Effectiveness of Bivalirudin in Percutaneous Peripheral Interventions: Data From a Real-World Registry
- Source :
- Journal of Endovascular Therapy. 17:31-36
- Publication Year :
- 2010
- Publisher :
- International Society of Endovascular Specialists, 2010.
-
Abstract
- PURPOSE To present real-world data to evaluate the safety and effectiveness of bivalirudin, a direct thrombin inhibitor, in an unselected group of patients undergoing percutaneous peripheral interventions (PPI). METHODS Data were extracted from a prospectively collected peripheral vascular registry developed for quality assurance measures at 2 centers. Of 398 consecutive patients (195 men; mean age 69.4+/-11.3 years) who underwent PPI in a 2-year period, 369 (92.7%) received bivalirudin (0.75 mg/kg bolus followed by a 1.75 mg/kg/h infusion) and 29 (7.3%) received unfractionated heparin (UFH). In the bivalirudin sample, critical limb ischemia was present in 28.0% of patients, TASC D lesion in 29.5%, and angiographic thrombus in 7.8% of vessels. Demographic, clinical, procedural, and angiographic variables and in-hospital complications were analyzed. All in-hospital adverse events were independently adjudicated. RESULTS Procedural success (
- Subjects :
- Male
medicine.medical_specialty
medicine.drug_class
medicine.medical_treatment
Hemorrhage
Constriction, Pathologic
Risk Assessment
Severity of Illness Index
law.invention
Randomized controlled trial
Ischemia
Risk Factors
law
Angioplasty
medicine
Humans
Bivalirudin
Radiology, Nuclear Medicine and imaging
Registries
Aged
Retrospective Studies
Aged, 80 and over
Peripheral Vascular Diseases
Inpatients
Chi-Square Distribution
Heparin
business.industry
Anticoagulant
Anticoagulants
Retrospective cohort study
Critical limb ischemia
Hirudins
Middle Aged
Iowa
Peptide Fragments
Recombinant Proteins
Surgery
Radiography
Logistic Models
Treatment Outcome
Amputation
Direct thrombin inhibitor
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
business
medicine.drug
Subjects
Details
- ISSN :
- 15451550 and 15266028
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Journal of Endovascular Therapy
- Accession number :
- edsair.doi.dedup.....08a9a84208fbe10e99f12b9420a7da91