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Safety and efficacy of sufentanil combined with midazolam in bronchoscopy under conscious sedation: retrospective study of 11,158 cases
- Source :
- Journal of thoracic disease. 11(10)
- Publication Year :
- 2019
-
Abstract
- BACKGROUND: The recommended conscious sedation for bronchoscopy is still lacking. The safety and efficacy of sufentanil combined with midazolam in bronchoscopy under conscious sedation is not well elucidated. METHODS: A retrospective analysis was conducted on patients who received bronchoscopy in the First Affiliated Hospital of Guangzhou Medical University from September 2013 to July 2017. Sufentanil and midazolam were administrated for conscious sedation. The drug dosage, sedating effect and adverse event were collected and analyzed. RESULTS: Totally, 7,089 males and 4,069 females aged 54±16 years (ranged from 4 to 94 years) were enrolled in this study. The dosage of sufentanil and midazolam were 5.25±1.28 mcg (2–13 mcg) and 2.03±0.51 mg (0.5–4.5 mg), respectively. Ninety-eight point six percent (10,998/11,158) of bronchoscopies were successfully completed, while 68.7% (7,670/11,158) procedures were performed with initial dose of 5 mcg sufentanil and 2 mg midazolam. Endobronchial biopsy, transbronchial lung biopsy (TBLB), transbronchial needle aspiration (TBNA), therapeutic procedure and asthma were predictors of giving incremental doses of sufentanil and midazolam (all OR >1, P1, P
- Subjects :
- Pulmonary and Respiratory Medicine
medicine.diagnostic_test
business.industry
Sedation
Retrospective cohort study
030204 cardiovascular system & hematology
medicine.disease
Bronchoscopies
Sufentanil
03 medical and health sciences
0302 clinical medicine
030228 respiratory system
Bronchoscopy
Anesthesia
Medicine
Midazolam
Original Article
medicine.symptom
business
Adverse effect
Asthma
medicine.drug
Subjects
Details
- ISSN :
- 20721439
- Volume :
- 11
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of thoracic disease
- Accession number :
- edsair.doi.dedup.....08b4d376a8b25a42c50b404e2bc73731