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SOME NEUROCHEMICAL ASPECTS OF FLUOROCITRATE INTOXICATION
- Source :
- Journal of Neurochemistry. 18:621-628
- Publication Year :
- 1971
- Publisher :
- Wiley, 1971.
-
Abstract
- — Some metabolic and biochemical effects of fluorocitrate were studied in vivo in rat brain and cat spinal cord. During the preconvulsant and convulsant phases of fluorocitrate poisoning the contents of free glutamate, glutamine and aspartate declined progressively, while that of alanine increased. Incorporation of 14C from [U-14C]glucose into these amino acids also decreased, although somewhat more gradually. GABA exhibited a biphasic change, its content rising after an initial decrease while its relative specific activity rose initially and subsequently diminished. Incorporation of 14C from [U-14C]glucose and [U-14C]lysine into neural protein declined sharply. The citric acid content rose markedly in rat brain and cat spinal cord. In rat brain the glycogen content declined but ATP and ammonia contents were unchanged. The significance of these results with respect to energy metabolism and the possible mechanism of the convulsions during fluorocitrate poisoning is discussed.
- Subjects :
- Central Nervous System
medicine.medical_specialty
Chromatography, Paper
Glutamine
Poison control
Nerve Tissue Proteins
Kidney
Biochemistry
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Adenosine Triphosphate
Neurochemical
Glutamates
Ammonia
Seizures
Internal medicine
medicine
Animals
Citrates
Amino Acids
Alanine
chemistry.chemical_classification
Aspartic Acid
Carbon Isotopes
Glycogen
business.industry
Aminobutyrates
Lysine
Poisoning
Glutamate receptor
Brain
Fluorine
Rats
Amino acid
Glucose
Endocrinology
Liver
Spinal Cord
chemistry
Spectrophotometry
Anesthesia
Cats
Convulsant
Colorimetry
Female
business
Subjects
Details
- ISSN :
- 14714159 and 00223042
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Journal of Neurochemistry
- Accession number :
- edsair.doi.dedup.....08b82477098a6a87db1cc848862c2e6f