Back to Search
Start Over
Impact of Cytomegalovirus Replication and Cytomegalovirus Serostatus on the Outcome of Patients with B Cell Lymphoma after Allogeneic Stem Cell Transplantation
- Source :
- Biology of Blood and Marrow Transplantation. 20:885-890
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Cytomegalovirus (CMV) replication after allogeneic hematopoietic stem cell transplantation (HSCT) was historically associated with increased nonrelapse mortality (NRM). More recently, different groups have reported an association between CMV replication and reduced risk of acute myeloid leukemia (AML) relapse. Given the conflicting results, we evaluated the impact of CMV replication and other covariates on the outcome of a retrospective cohort of 265 adults with B cell lymphoma receiving allogeneic HSCT from HLA-identical siblings or alternative donors. In time-dependent multivariate analysis, CMV replication, evaluated by pp65 antigenemia, had no independent effect on the risk of relapse (hazard ratio [HR], 1.0; 95% confidence interval [CI], .6 to 1.6; P = .9), although it was associated with a reduced overall survival (HR, 2.0; 95% CI, 1.3 to 3.2; P = .001) and an increased NRM (HR, 2.5; 95% CI, 1.1 to 5.3; P = .01). Consistently, donor and/or recipient CMV seropositivity were not associated with a different outcome relative to CMV double-negative serostatus. In multivariate models, a diagnosis of follicular lymphoma (P
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Lymphoma, B-Cell
Transplantation Conditioning
Lymphoma
Adolescent
medicine.medical_treatment
Follicular lymphoma
Congenital cytomegalovirus infection
Cytomegalovirus
Hematopoietic stem cell transplantation
Virus Replication
Cohort Studies
Young Adult
hemic and lymphatic diseases
Internal medicine
medicine
Humans
Transplantation, Homologous
B-cell lymphoma
Aged
Retrospective Studies
Transplantation
business.industry
Hazard ratio
Hematopoietic Stem Cell Transplantation
virus diseases
Hematology
Middle Aged
medicine.disease
Treatment Outcome
Allogeneic hematopoietic stem cell transplantation
Cytomegalovirus Infections
Immunology
Female
Cytomegalovirus (CMV)
Serostatus
business
Subjects
Details
- ISSN :
- 10838791
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Biology of Blood and Marrow Transplantation
- Accession number :
- edsair.doi.dedup.....08db82694128762517af7307c189d106