Supplementary Figure 1 from Venetoclax-based Rational Combinations are Effective in Models of MYCN-amplified Neuroblastoma

Supplemental Figure 1. NVP-CGM097 and venetoclax combination cell viability assays. Cell viability assays were performed for 16h treatment of NVP-CGM097, venetoclax, or combination at indicated concentrations, with bliss synergy scores in (A) MYCN-wild-type, p53-wild-type, (B) MYCN-amplified, p53-mutant, and (C) MYCN-wild-type, p53-mutant NB cell lines. Red indicates synergy, blue indicates antagonism. (D) Plot of Bliss sum of cell lines in A-C along with cell lines in Fig. 1B, calculated by the summation of the bliss synergy scores across the doses presented.