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The Complete Amino Acid Sequence of Bovine Serum Amyloid Protein A (SAA) and of Subspecies of the Tissue-Deposited Amyloid Fibril Protein A
- Source :
- Scandinavian Journal of Immunology. 35:217-224
- Publication Year :
- 1992
- Publisher :
- Wiley, 1992.
-
Abstract
- Bovine serum amyloid A (SAA) was isolated from the acute phase high density lipoprotein (HDL) fraction of a cow suffering from acute mastitis. The elucidated primary structure revealed a protein consisting of 112 amino acid residues. Compared with SAA proteins from other species, the bovine protein was shown to have an insertion of nine amino acid residues between positions 69 and 70. No microheterogeneity could be observed in the protein. Amyloid fibrils extracted from the kidneys were found to contain at least three subspecies of protein AA, consisting of 68, 81 and about 110 amino acid residues. The amino acid sequences established for the protein AA subspecies revealed no microheterogeneity, and were identical to that elucidated for protein SAA.
- Subjects :
- Molecular Sequence Data
Immunology
Sequence alignment
Biology
Kidney
Sequence Homology, Nucleic Acid
Animals
Humans
Amino Acid Sequence
Serum amyloid A
Bovine serum albumin
Mastitis, Bovine
Peptide sequence
Chromatography, High Pressure Liquid
Serum Amyloid A Protein
chemistry.chemical_classification
Protein primary structure
General Medicine
Peptide Fragments
Amino acid
Biochemistry
chemistry
Chromatography, Gel
biology.protein
Cattle
Female
Lipoproteins, HDL
Protein A
Sequence Alignment
Subjects
Details
- ISSN :
- 13653083 and 03009475
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Scandinavian Journal of Immunology
- Accession number :
- edsair.doi.dedup.....08faebeab4702cb14f0c847556c95f54