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Elevated Brain 5-Hydroxytryptophol Levels in Experimental Portal-Systemic Encephalopathy
- Source :
- Pharmacology & Toxicology. 80:187-190
- Publication Year :
- 1997
- Publisher :
- Wiley, 1997.
-
Abstract
- Brain tissue levels of the two serotonin metabolites 5-hydroxytryptophol and 5-hydroxyindole-3-acetic acid (5-HIAA) were measured in porta-caval shunted rats, an in vivo model of portal-systemic encephalopathy. An intraperitoneal challenge of L-tryptophan (280 mg/kg body weight) to sham-operated rats was also instituted to increase the brain serotonin metabolism in these rats. The results revealed significant increases in 5-hydroxytryptophol (by 31%) and 5-HIAA (by 87%) brain levels in porta-caval shunted rats as compared to sham-operated controls. The brain 5-hydroxytryptophol-to-5-HIAA ratio was lower in the porta-caval shunted rats. The 5-hydroxytryptophol levels in sham rats after the L-tryptophan challenge were intermediate between the porta-caval shunted and sham rats but not statistically significant for either group. These results suggest that increased brain 5-hydroxytryptophol levels might be associated with the pathogenesis of portal-systemic encephalopathy. Further, the elevated brain 5-hydroxytryptophol levels in experimental portal-systemic encephalopathy are probably a result of the increased brain serotonin metabolism prevailing in this condition rather than changes in the brain redox potential.
- Subjects :
- Male
medicine.medical_specialty
Health, Toxicology and Mutagenesis
Central nervous system
Encephalopathy
Neurocognitive Disorders
Biology
Toxicology
Rats, Sprague-Dawley
Pathogenesis
Central nervous system disease
chemistry.chemical_compound
In vivo
Internal medicine
medicine
Animals
Neurotransmitter
Pharmacology
Portacaval Shunt, Surgical
Metabolic disorder
Tryptophan
Brain
Hydroxyindoleacetic Acid
medicine.disease
Rats
Endocrinology
medicine.anatomical_structure
chemistry
Hydroxytryptophol
Serotonin
Subjects
Details
- ISSN :
- 16000773 and 09019928
- Volume :
- 80
- Database :
- OpenAIRE
- Journal :
- Pharmacology & Toxicology
- Accession number :
- edsair.doi.dedup.....09087bce3a68ca9299481d5181126c3c