Back to Search
Start Over
Hippocampal sclerosis without visually detectable hippocampal MRI abnormalities: automated subfield volumetric analysis
- Source :
- Japanese journal of radiology. 38(11)
- Publication Year :
- 2020
-
Abstract
- This study aims to investigate hippocampal subfield volumes in patients with hippocampal sclerosis (HS) without visually detectable MRI abnormalities and to determine the diagnostic accuracy using hippocampal subfield volumes. We examined 46 patients with unilateral HS who had a histopathological diagnosis, and 54 controls. The patients were divided into two groups; visually detectable HS (n = 26) and undetectable HS (n = 20) on MRI. The volumes of hippocampal subfield using FreeSurfer were compared among the three groups. Diagnostic accuracy was calculated as the AUC of ROC using cutoff values for each individual subfield. Compared with the controls, visually detectable HS showed significantly reduced volumes of all the hippocampal subfields and entire hippocampus, whereas visually undetectable HS showed significant atrophy only in the CA3 and hippocampus-amygdala-transition-area. To diagnose visually undetectable HS, the CA3 volumes had AUC of 0.719, which was higher than AUC of 0.614 based on the entire hippocampal volumes. Visually undetectable HS demonstrated volume reductions in the CA3. Further, the CA3 volumes was more useful to diagnose visually undetectable HS compared with the entire hippocampal volumes.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
genetic structures
Entire hippocampus
Hippocampus
Diagnostic accuracy
Hippocampal formation
030218 nuclear medicine & medical imaging
03 medical and health sciences
Epilepsy
0302 clinical medicine
Atrophy
Image Interpretation, Computer-Assisted
Medicine
Humans
Radiology, Nuclear Medicine and imaging
In patient
Hippocampal sclerosis
Sclerosis
business.industry
Reproducibility of Results
Organ Size
medicine.disease
Magnetic Resonance Imaging
nervous system
Epilepsy, Temporal Lobe
030220 oncology & carcinogenesis
Female
business
Subjects
Details
- ISSN :
- 1867108X
- Volume :
- 38
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Japanese journal of radiology
- Accession number :
- edsair.doi.dedup.....0924bd52d88da347238eb87764b6b13b