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Oral hypoglycaemic agent metformin reduces oxidative stress and improves kidney histologyin streptozotocin-induced diabetic rats
- Source :
- Nigerian Journal of Basic and Applied Sciences; Vol 26, No 2 (2018); 54-58
- Publication Year :
- 2019
- Publisher :
- African Journals Online (AJOL), 2019.
-
Abstract
- ABSTRACT Background: Persistent hyperglycaemia results in complications in diabetes mellitus (DM) and metformin is the baseline drug used in diabetic management. The effect of metformin on fasting blood glucose (FBG), homogenized kidney tissue malonyldehyde (MDA), protein carbonyls (PCO), total antioxidant capacity (TAC) and histology in streptozotocin-induced diabetic rats was investigated. Methods: Eighteen Sprague Dawley rats were assigned into three groups (n= 6 rats per group i.e. A; negative control on distilled water, B; positive control on distilled water and C; on 100 mg/kg/day metformin groups. Diabetes mellitus (DM) was induced using streptozotocin 65 mg/kg intraperitoneally and treatments were given daily by oral gavage for 3 weeks. Plasma fasting blood glucose (FBG), kidney tissue oxidative stress markers and histology were determined. Results: The results showed that FBG, MDA, and PCO levels were significantly higher in B group compared to A group, and lower in C group compared to B. The TAC level was significantly lower in B compared to A and higher in C compared to B group of rats. However, though histological study shows improvement in kidney histology in all treatments, kidney weight did not differ. Conclution: The results suggest that, metformin reduces oxidative stress in streptozotocin-induced diabetic rats possibly through its antihyperglycaemic effect.
- Subjects :
- Kidney
medicine.medical_specialty
endocrine system diseases
business.industry
Diabetes, Metformin, Oxidative stress, Streptozotocin, Kidney
nutritional and metabolic diseases
Histology
medicine.disease
Streptozotocin
medicine.disease_cause
Metformin
medicine.anatomical_structure
Kidney histology
Endocrinology
Distilled water
Diabetes mellitus
Internal medicine
medicine
business
Oxidative stress
medicine.drug
Subjects
Details
- ISSN :
- 07945698
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Nigerian Journal of Basic and Applied Sciences
- Accession number :
- edsair.doi.dedup.....092a4f4db3be9046ed7544981b3950f6