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Efficacy of commercial vaccines against newly emerging avian influenza H5N8 virus in Egypt
- Source :
- Scientific Reports, Scientific Reports, Vol 8, Iss 1, Pp 1-6 (2018)
- Publication Year :
- 2018
- Publisher :
- Nature Publishing Group UK, 2018.
-
Abstract
- The newly emerging, highly pathogenic avian influenza (HPAI) H5N8 virus of clade 2.3.4.4 was recently detected in wild birds and domestic poultry in Egypt in the 2016/2017 winter season. Vaccination based on commercial H5 vaccines is used as an essential control strategy in Egyptian poultry. Here, we studied the efficacy of the eight most common commercial H5 poultry vaccines in the Egyptian market and compared them with an experimental vaccine based on the Egyptian LPAI H5N8 virus that was prepared by using reverse genetics. The experimental vaccine and Re-5 commercial vaccine were able to completely protect chickens and significantly reduce virus shedding. Our results indicate that most of the commercial poultry H5 vaccines used in the present study were ineffective because the seed viruses in these vaccines are genetically distinct from the H5N8 viruses currently circulating in Egypt. Although some of the commercial vaccines protected chickens from mortality, they failed to prevent chickens from shedding the virus. Accordingly, we recommend updating and reinforcing the H5N8 prevention and control strategies in Egypt. The vaccination strategy should be reconsidered based on currently circulating viruses.
- Subjects :
- 0301 basic medicine
Highly pathogenic
lcsh:Medicine
Biology
medicine.disease_cause
Virus
Article
03 medical and health sciences
Influenza A virus
medicine
Animals
Influenza A Virus, H5N8 Subtype
Viral shedding
lcsh:Science
Clade
Multidisciplinary
lcsh:R
Virology
Reverse genetics
Influenza A virus subtype H5N1
Vaccination
030104 developmental biology
Influenza Vaccines
Influenza in Birds
lcsh:Q
Egypt
Chickens
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....092dd8f282a5519c1880e9c0a5dba273